(1R,4′S)-4-(tert-Butyl­dimethyl­silan­oxy)-1-[2,2-dimethyl-3-(p-tolyl­sulfon­yl)-1,3-oxazolidin-4-yl]but-2-yn-1-ol

The chiral title compound, C(22)H(35)NO(5)SSi, is a precursor of novel furan­omycin derivatives. It crystallizes with two molecules in the asymmetric unit; these show different conformations of the silyl substitutent, as indicated by the Si—O—C—C torsion angles of 41.4 (7) and −84.5 (5)° in the two...

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Detalles Bibliográficos
Autores principales: Erdsack, Jörg, Schürmann, Markus, Preut, Hans, Krause, Norbert
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961448/
https://www.ncbi.nlm.nih.gov/pubmed/21202678
http://dx.doi.org/10.1107/S1600536808014906
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author Erdsack, Jörg
Schürmann, Markus
Preut, Hans
Krause, Norbert
author_facet Erdsack, Jörg
Schürmann, Markus
Preut, Hans
Krause, Norbert
author_sort Erdsack, Jörg
collection PubMed
description The chiral title compound, C(22)H(35)NO(5)SSi, is a precursor of novel furan­omycin derivatives. It crystallizes with two molecules in the asymmetric unit; these show different conformations of the silyl substitutent, as indicated by the Si—O—C—C torsion angles of 41.4 (7) and −84.5 (5)° in the two mol­ecules. The anti configuration of the adjacent stereogenic centers is consistent with the Felkin–Anh model. Each of the two crystallographically independent mol­ecules is connected with a neighbouring mol­ecule of the same type via two symmetry-equivalent O—H⋯O hydrogen bonds.
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spelling pubmed-29614482010-12-30 (1R,4′S)-4-(tert-Butyl­dimethyl­silan­oxy)-1-[2,2-dimethyl-3-(p-tolyl­sulfon­yl)-1,3-oxazolidin-4-yl]but-2-yn-1-ol Erdsack, Jörg Schürmann, Markus Preut, Hans Krause, Norbert Acta Crystallogr Sect E Struct Rep Online Organic Papers The chiral title compound, C(22)H(35)NO(5)SSi, is a precursor of novel furan­omycin derivatives. It crystallizes with two molecules in the asymmetric unit; these show different conformations of the silyl substitutent, as indicated by the Si—O—C—C torsion angles of 41.4 (7) and −84.5 (5)° in the two mol­ecules. The anti configuration of the adjacent stereogenic centers is consistent with the Felkin–Anh model. Each of the two crystallographically independent mol­ecules is connected with a neighbouring mol­ecule of the same type via two symmetry-equivalent O—H⋯O hydrogen bonds. International Union of Crystallography 2008-05-30 /pmc/articles/PMC2961448/ /pubmed/21202678 http://dx.doi.org/10.1107/S1600536808014906 Text en © Erdsack et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Erdsack, Jörg
Schürmann, Markus
Preut, Hans
Krause, Norbert
(1R,4′S)-4-(tert-Butyl­dimethyl­silan­oxy)-1-[2,2-dimethyl-3-(p-tolyl­sulfon­yl)-1,3-oxazolidin-4-yl]but-2-yn-1-ol
title (1R,4′S)-4-(tert-Butyl­dimethyl­silan­oxy)-1-[2,2-dimethyl-3-(p-tolyl­sulfon­yl)-1,3-oxazolidin-4-yl]but-2-yn-1-ol
title_full (1R,4′S)-4-(tert-Butyl­dimethyl­silan­oxy)-1-[2,2-dimethyl-3-(p-tolyl­sulfon­yl)-1,3-oxazolidin-4-yl]but-2-yn-1-ol
title_fullStr (1R,4′S)-4-(tert-Butyl­dimethyl­silan­oxy)-1-[2,2-dimethyl-3-(p-tolyl­sulfon­yl)-1,3-oxazolidin-4-yl]but-2-yn-1-ol
title_full_unstemmed (1R,4′S)-4-(tert-Butyl­dimethyl­silan­oxy)-1-[2,2-dimethyl-3-(p-tolyl­sulfon­yl)-1,3-oxazolidin-4-yl]but-2-yn-1-ol
title_short (1R,4′S)-4-(tert-Butyl­dimethyl­silan­oxy)-1-[2,2-dimethyl-3-(p-tolyl­sulfon­yl)-1,3-oxazolidin-4-yl]but-2-yn-1-ol
title_sort (1r,4′s)-4-(tert-butyl­dimethyl­silan­oxy)-1-[2,2-dimethyl-3-(p-tolyl­sulfon­yl)-1,3-oxazolidin-4-yl]but-2-yn-1-ol
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961448/
https://www.ncbi.nlm.nih.gov/pubmed/21202678
http://dx.doi.org/10.1107/S1600536808014906
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