Cargando…
2-Bromomethyl-N-isopropyl-7,8-dimethoxy-1,2-dihydro-1,3-oxazolo[3,2-a]quinoline-4-carboxamide
In the title compound, C(18)H(21)BrN(2)O(5), conjugation between the π-donating N—C—O fragment and the π-withdrawing carbonyl group results in considerable redistribution of the electron density within the dihydropyridinol ring. This effect is also promoted by the formation of an intramolecular N—H...
| Autores principales: | , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2008
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961529/ https://www.ncbi.nlm.nih.gov/pubmed/21202555 http://dx.doi.org/10.1107/S1600536808013378 |
| _version_ | 1782189004521734144 |
|---|---|
| author | Shishkina, Svetlana V. Shishkin, Oleg V. Ukrainets, Igor V. Bereznyakova, Nataliya L. Davidenko, Alexandra A. |
| author_facet | Shishkina, Svetlana V. Shishkin, Oleg V. Ukrainets, Igor V. Bereznyakova, Nataliya L. Davidenko, Alexandra A. |
| author_sort | Shishkina, Svetlana V. |
| collection | PubMed |
| description | In the title compound, C(18)H(21)BrN(2)O(5), conjugation between the π-donating N—C—O fragment and the π-withdrawing carbonyl group results in considerable redistribution of the electron density within the dihydropyridinol ring. This effect is also promoted by the formation of an intramolecular N—H⋯O hydrogen bond. The five-membered heterocycle is disordered over two envelope conformations in a 0.35:0.65 ratio. |
| format | Text |
| id | pubmed-2961529 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2008 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29615292010-12-30 2-Bromomethyl-N-isopropyl-7,8-dimethoxy-1,2-dihydro-1,3-oxazolo[3,2-a]quinoline-4-carboxamide Shishkina, Svetlana V. Shishkin, Oleg V. Ukrainets, Igor V. Bereznyakova, Nataliya L. Davidenko, Alexandra A. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(18)H(21)BrN(2)O(5), conjugation between the π-donating N—C—O fragment and the π-withdrawing carbonyl group results in considerable redistribution of the electron density within the dihydropyridinol ring. This effect is also promoted by the formation of an intramolecular N—H⋯O hydrogen bond. The five-membered heterocycle is disordered over two envelope conformations in a 0.35:0.65 ratio. International Union of Crystallography 2008-05-10 /pmc/articles/PMC2961529/ /pubmed/21202555 http://dx.doi.org/10.1107/S1600536808013378 Text en © Shishkina et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| spellingShingle | Organic Papers Shishkina, Svetlana V. Shishkin, Oleg V. Ukrainets, Igor V. Bereznyakova, Nataliya L. Davidenko, Alexandra A. 2-Bromomethyl-N-isopropyl-7,8-dimethoxy-1,2-dihydro-1,3-oxazolo[3,2-a]quinoline-4-carboxamide |
| title | 2-Bromomethyl-N-isopropyl-7,8-dimethoxy-1,2-dihydro-1,3-oxazolo[3,2-a]quinoline-4-carboxamide |
| title_full | 2-Bromomethyl-N-isopropyl-7,8-dimethoxy-1,2-dihydro-1,3-oxazolo[3,2-a]quinoline-4-carboxamide |
| title_fullStr | 2-Bromomethyl-N-isopropyl-7,8-dimethoxy-1,2-dihydro-1,3-oxazolo[3,2-a]quinoline-4-carboxamide |
| title_full_unstemmed | 2-Bromomethyl-N-isopropyl-7,8-dimethoxy-1,2-dihydro-1,3-oxazolo[3,2-a]quinoline-4-carboxamide |
| title_short | 2-Bromomethyl-N-isopropyl-7,8-dimethoxy-1,2-dihydro-1,3-oxazolo[3,2-a]quinoline-4-carboxamide |
| title_sort | 2-bromomethyl-n-isopropyl-7,8-dimethoxy-1,2-dihydro-1,3-oxazolo[3,2-a]quinoline-4-carboxamide |
| topic | Organic Papers |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961529/ https://www.ncbi.nlm.nih.gov/pubmed/21202555 http://dx.doi.org/10.1107/S1600536808013378 |
| work_keys_str_mv | AT shishkinasvetlanav 2bromomethylnisopropyl78dimethoxy12dihydro13oxazolo32aquinoline4carboxamide AT shishkinolegv 2bromomethylnisopropyl78dimethoxy12dihydro13oxazolo32aquinoline4carboxamide AT ukrainetsigorv 2bromomethylnisopropyl78dimethoxy12dihydro13oxazolo32aquinoline4carboxamide AT bereznyakovanataliyal 2bromomethylnisopropyl78dimethoxy12dihydro13oxazolo32aquinoline4carboxamide AT davidenkoalexandraa 2bromomethylnisopropyl78dimethoxy12dihydro13oxazolo32aquinoline4carboxamide |