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(1S,3S,4S)-tert-Butyl N-[1-benzyl-3-hydr­oxy-5-phenyl-4-(picolinamido)pent­yl]carbamate

The title compound, C(29)H(35)N(3)O(4), was obtained by the reaction of (2S,4S,5S)-tert-butyl N-(4-amino-1-benzyl-3-hydr­oxy-5-phenyl­pent­yl)carbamate and picolinic acid using oxalyl chloride as a chlorinating reagent to activate the carboxyl group. In the crystal structure there are two mol­ecules...

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Detalles Bibliográficos
Autores principales: Zheng, Jian-Feng, Huang, Su-Yu, Guo, Jian-Nan, Zhang, Yu, Jin, Li-Ren
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961835/
https://www.ncbi.nlm.nih.gov/pubmed/21202980
http://dx.doi.org/10.1107/S1600536808018965
Descripción
Sumario:The title compound, C(29)H(35)N(3)O(4), was obtained by the reaction of (2S,4S,5S)-tert-butyl N-(4-amino-1-benzyl-3-hydr­oxy-5-phenyl­pent­yl)carbamate and picolinic acid using oxalyl chloride as a chlorinating reagent to activate the carboxyl group. In the crystal structure there are two mol­ecules in the asymmetric unit, which are aligned edge-to-face. In one mol­ecule, the pyridyl ring forms a dihedral angle of 22.0 (1)° with the phenyl ring of the terminal benzyl group and 14.3 (1)° with the other phenyl ring; in the other mol­ecule, the corresponding angles are 12.1 (1) and 10.6 (1)°, respectively. The packing is stabilized by inter­molecular hydrogen bonds and C—H⋯π inter­actions.