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(1S,3S,4S)-tert-Butyl N-[1-benzyl-3-hydroxy-5-phenyl-4-(picolinamido)pentyl]carbamate
The title compound, C(29)H(35)N(3)O(4), was obtained by the reaction of (2S,4S,5S)-tert-butyl N-(4-amino-1-benzyl-3-hydroxy-5-phenylpentyl)carbamate and picolinic acid using oxalyl chloride as a chlorinating reagent to activate the carboxyl group. In the crystal structure there are two molecules...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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International Union of Crystallography
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961835/ https://www.ncbi.nlm.nih.gov/pubmed/21202980 http://dx.doi.org/10.1107/S1600536808018965 |
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author | Zheng, Jian-Feng Huang, Su-Yu Guo, Jian-Nan Zhang, Yu Jin, Li-Ren |
author_facet | Zheng, Jian-Feng Huang, Su-Yu Guo, Jian-Nan Zhang, Yu Jin, Li-Ren |
author_sort | Zheng, Jian-Feng |
collection | PubMed |
description | The title compound, C(29)H(35)N(3)O(4), was obtained by the reaction of (2S,4S,5S)-tert-butyl N-(4-amino-1-benzyl-3-hydroxy-5-phenylpentyl)carbamate and picolinic acid using oxalyl chloride as a chlorinating reagent to activate the carboxyl group. In the crystal structure there are two molecules in the asymmetric unit, which are aligned edge-to-face. In one molecule, the pyridyl ring forms a dihedral angle of 22.0 (1)° with the phenyl ring of the terminal benzyl group and 14.3 (1)° with the other phenyl ring; in the other molecule, the corresponding angles are 12.1 (1) and 10.6 (1)°, respectively. The packing is stabilized by intermolecular hydrogen bonds and C—H⋯π interactions. |
format | Text |
id | pubmed-2961835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-29618352010-12-30 (1S,3S,4S)-tert-Butyl N-[1-benzyl-3-hydroxy-5-phenyl-4-(picolinamido)pentyl]carbamate Zheng, Jian-Feng Huang, Su-Yu Guo, Jian-Nan Zhang, Yu Jin, Li-Ren Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(29)H(35)N(3)O(4), was obtained by the reaction of (2S,4S,5S)-tert-butyl N-(4-amino-1-benzyl-3-hydroxy-5-phenylpentyl)carbamate and picolinic acid using oxalyl chloride as a chlorinating reagent to activate the carboxyl group. In the crystal structure there are two molecules in the asymmetric unit, which are aligned edge-to-face. In one molecule, the pyridyl ring forms a dihedral angle of 22.0 (1)° with the phenyl ring of the terminal benzyl group and 14.3 (1)° with the other phenyl ring; in the other molecule, the corresponding angles are 12.1 (1) and 10.6 (1)°, respectively. The packing is stabilized by intermolecular hydrogen bonds and C—H⋯π interactions. International Union of Crystallography 2008-06-28 /pmc/articles/PMC2961835/ /pubmed/21202980 http://dx.doi.org/10.1107/S1600536808018965 Text en © Zheng et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Zheng, Jian-Feng Huang, Su-Yu Guo, Jian-Nan Zhang, Yu Jin, Li-Ren (1S,3S,4S)-tert-Butyl N-[1-benzyl-3-hydroxy-5-phenyl-4-(picolinamido)pentyl]carbamate |
title | (1S,3S,4S)-tert-Butyl N-[1-benzyl-3-hydroxy-5-phenyl-4-(picolinamido)pentyl]carbamate |
title_full | (1S,3S,4S)-tert-Butyl N-[1-benzyl-3-hydroxy-5-phenyl-4-(picolinamido)pentyl]carbamate |
title_fullStr | (1S,3S,4S)-tert-Butyl N-[1-benzyl-3-hydroxy-5-phenyl-4-(picolinamido)pentyl]carbamate |
title_full_unstemmed | (1S,3S,4S)-tert-Butyl N-[1-benzyl-3-hydroxy-5-phenyl-4-(picolinamido)pentyl]carbamate |
title_short | (1S,3S,4S)-tert-Butyl N-[1-benzyl-3-hydroxy-5-phenyl-4-(picolinamido)pentyl]carbamate |
title_sort | (1s,3s,4s)-tert-butyl n-[1-benzyl-3-hydroxy-5-phenyl-4-(picolinamido)pentyl]carbamate |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961835/ https://www.ncbi.nlm.nih.gov/pubmed/21202980 http://dx.doi.org/10.1107/S1600536808018965 |
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