Degradation of atorvastatin: (1R,2S,4S,5S)-4-(4-fluoro­phen­yl)-2-hydro­peroxy-4-hydr­oxy-2-isopropyl-N,5-diphenyl-3,6-dioxabicyclo­[3.1.0]hexane-1-carboxamide

The degradation of atorvastatin calcium in methanol and hydrogen peroxide results in the crystallization of the title compound, C(26)H(24)FNO(6), which shows several differences compared with the starting compound. In the crystal structure of the title compound, intra- and inter­molecular hydrogen b...

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Detalles Bibliográficos
Autores principales: Ashfaq, Muhammad, Tahir, Muhammad Nawaz, Khan, Islam Ullah, Iqbal, Mohammad S., Arshad, Muhammad Nadeem
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962052/
https://www.ncbi.nlm.nih.gov/pubmed/21203252
http://dx.doi.org/10.1107/S1600536808022265
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author Ashfaq, Muhammad
Tahir, Muhammad Nawaz
Khan, Islam Ullah
Iqbal, Mohammad S.
Arshad, Muhammad Nadeem
author_facet Ashfaq, Muhammad
Tahir, Muhammad Nawaz
Khan, Islam Ullah
Iqbal, Mohammad S.
Arshad, Muhammad Nadeem
author_sort Ashfaq, Muhammad
collection PubMed
description The degradation of atorvastatin calcium in methanol and hydrogen peroxide results in the crystallization of the title compound, C(26)H(24)FNO(6), which shows several differences compared with the starting compound. In the crystal structure of the title compound, intra- and inter­molecular hydrogen bonding is found.
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spelling pubmed-29620522010-12-30 Degradation of atorvastatin: (1R,2S,4S,5S)-4-(4-fluoro­phen­yl)-2-hydro­peroxy-4-hydr­oxy-2-isopropyl-N,5-diphenyl-3,6-dioxabicyclo­[3.1.0]hexane-1-carboxamide Ashfaq, Muhammad Tahir, Muhammad Nawaz Khan, Islam Ullah Iqbal, Mohammad S. Arshad, Muhammad Nadeem Acta Crystallogr Sect E Struct Rep Online Organic Papers The degradation of atorvastatin calcium in methanol and hydrogen peroxide results in the crystallization of the title compound, C(26)H(24)FNO(6), which shows several differences compared with the starting compound. In the crystal structure of the title compound, intra- and inter­molecular hydrogen bonding is found. International Union of Crystallography 2008-07-19 /pmc/articles/PMC2962052/ /pubmed/21203252 http://dx.doi.org/10.1107/S1600536808022265 Text en © Ashfaq et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Ashfaq, Muhammad
Tahir, Muhammad Nawaz
Khan, Islam Ullah
Iqbal, Mohammad S.
Arshad, Muhammad Nadeem
Degradation of atorvastatin: (1R,2S,4S,5S)-4-(4-fluoro­phen­yl)-2-hydro­peroxy-4-hydr­oxy-2-isopropyl-N,5-diphenyl-3,6-dioxabicyclo­[3.1.0]hexane-1-carboxamide
title Degradation of atorvastatin: (1R,2S,4S,5S)-4-(4-fluoro­phen­yl)-2-hydro­peroxy-4-hydr­oxy-2-isopropyl-N,5-diphenyl-3,6-dioxabicyclo­[3.1.0]hexane-1-carboxamide
title_full Degradation of atorvastatin: (1R,2S,4S,5S)-4-(4-fluoro­phen­yl)-2-hydro­peroxy-4-hydr­oxy-2-isopropyl-N,5-diphenyl-3,6-dioxabicyclo­[3.1.0]hexane-1-carboxamide
title_fullStr Degradation of atorvastatin: (1R,2S,4S,5S)-4-(4-fluoro­phen­yl)-2-hydro­peroxy-4-hydr­oxy-2-isopropyl-N,5-diphenyl-3,6-dioxabicyclo­[3.1.0]hexane-1-carboxamide
title_full_unstemmed Degradation of atorvastatin: (1R,2S,4S,5S)-4-(4-fluoro­phen­yl)-2-hydro­peroxy-4-hydr­oxy-2-isopropyl-N,5-diphenyl-3,6-dioxabicyclo­[3.1.0]hexane-1-carboxamide
title_short Degradation of atorvastatin: (1R,2S,4S,5S)-4-(4-fluoro­phen­yl)-2-hydro­peroxy-4-hydr­oxy-2-isopropyl-N,5-diphenyl-3,6-dioxabicyclo­[3.1.0]hexane-1-carboxamide
title_sort degradation of atorvastatin: (1r,2s,4s,5s)-4-(4-fluoro­phen­yl)-2-hydro­peroxy-4-hydr­oxy-2-isopropyl-n,5-diphenyl-3,6-dioxabicyclo­[3.1.0]hexane-1-carboxamide
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962052/
https://www.ncbi.nlm.nih.gov/pubmed/21203252
http://dx.doi.org/10.1107/S1600536808022265
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