6β-Chloro-5α-hydr­oxy-20-oxopregnan-3β-yl acetate

The title steroid, C(23)H(35)ClO(4), is a pregnane derivative prepared by ring opening of the corresponding 5α,6α-ep­oxy steroid with BiCl(3). There are two symmetry-independent mol­ecules in the asymmetric unit that show no significant differences concerning bond lengths and angles. The conformatio...

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Detalles Bibliográficos
Autores principales: Pinto, Rui M. A., Salvador, Jorge A. R., Paixão, José A., Matos Beja, Ana, Ramos Silva, Manuela
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962054/
https://www.ncbi.nlm.nih.gov/pubmed/21203139
http://dx.doi.org/10.1107/S1600536808019478
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author Pinto, Rui M. A.
Salvador, Jorge A. R.
Paixão, José A.
Matos Beja, Ana
Ramos Silva, Manuela
author_facet Pinto, Rui M. A.
Salvador, Jorge A. R.
Paixão, José A.
Matos Beja, Ana
Ramos Silva, Manuela
author_sort Pinto, Rui M. A.
collection PubMed
description The title steroid, C(23)H(35)ClO(4), is a pregnane derivative prepared by ring opening of the corresponding 5α,6α-ep­oxy steroid with BiCl(3). There are two symmetry-independent mol­ecules in the asymmetric unit that show no significant differences concerning bond lengths and angles. The conformation of the six-membered rings in both mol­ecules is close to a chair form, while the five-membered ring adopts an envelope conformation. All rings in both mol­ecules are trans-fused. The mol­ecules are held together by an extensive O—H⋯O hydrogen-bonding network.
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spelling pubmed-29620542010-12-30 6β-Chloro-5α-hydr­oxy-20-oxopregnan-3β-yl acetate Pinto, Rui M. A. Salvador, Jorge A. R. Paixão, José A. Matos Beja, Ana Ramos Silva, Manuela Acta Crystallogr Sect E Struct Rep Online Organic Papers The title steroid, C(23)H(35)ClO(4), is a pregnane derivative prepared by ring opening of the corresponding 5α,6α-ep­oxy steroid with BiCl(3). There are two symmetry-independent mol­ecules in the asymmetric unit that show no significant differences concerning bond lengths and angles. The conformation of the six-membered rings in both mol­ecules is close to a chair form, while the five-membered ring adopts an envelope conformation. All rings in both mol­ecules are trans-fused. The mol­ecules are held together by an extensive O—H⋯O hydrogen-bonding network. International Union of Crystallography 2008-07-05 /pmc/articles/PMC2962054/ /pubmed/21203139 http://dx.doi.org/10.1107/S1600536808019478 Text en © Pinto et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Pinto, Rui M. A.
Salvador, Jorge A. R.
Paixão, José A.
Matos Beja, Ana
Ramos Silva, Manuela
6β-Chloro-5α-hydr­oxy-20-oxopregnan-3β-yl acetate
title 6β-Chloro-5α-hydr­oxy-20-oxopregnan-3β-yl acetate
title_full 6β-Chloro-5α-hydr­oxy-20-oxopregnan-3β-yl acetate
title_fullStr 6β-Chloro-5α-hydr­oxy-20-oxopregnan-3β-yl acetate
title_full_unstemmed 6β-Chloro-5α-hydr­oxy-20-oxopregnan-3β-yl acetate
title_short 6β-Chloro-5α-hydr­oxy-20-oxopregnan-3β-yl acetate
title_sort 6β-chloro-5α-hydr­oxy-20-oxopregnan-3β-yl acetate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962054/
https://www.ncbi.nlm.nih.gov/pubmed/21203139
http://dx.doi.org/10.1107/S1600536808019478
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