A role for accessory genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4

Lysis inhibition (LIN) is a known feature of the T-even family of bacteriophages. Despite its historical role in the development of modern molecular genetics, many aspects of this phenomenon remain mostly unexplained. The key element of LIN is an interaction between two phage-encoded proteins, the T...

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Autores principales: Golec, Piotr, Wiczk, Aleksandra, Majchrzyk, Anna, Łoś, Joanna M., Węgrzyn, Grzegorz, Łoś, Marcin
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962797/
https://www.ncbi.nlm.nih.gov/pubmed/20945083
http://dx.doi.org/10.1007/s11262-010-0532-1
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author Golec, Piotr
Wiczk, Aleksandra
Majchrzyk, Anna
Łoś, Joanna M.
Węgrzyn, Grzegorz
Łoś, Marcin
author_facet Golec, Piotr
Wiczk, Aleksandra
Majchrzyk, Anna
Łoś, Joanna M.
Węgrzyn, Grzegorz
Łoś, Marcin
author_sort Golec, Piotr
collection PubMed
description Lysis inhibition (LIN) is a known feature of the T-even family of bacteriophages. Despite its historical role in the development of modern molecular genetics, many aspects of this phenomenon remain mostly unexplained. The key element of LIN is an interaction between two phage-encoded proteins, the T holin and the RI antiholin. This interaction is stabilized by RIII. In this report, we demonstrate the results of genetic experiments which suggest a synergistic action of two accessory proteins of bacteriophage T4, RI.-1, and RI.1 with RIII in the regulation of LIN.
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spelling pubmed-29627972010-11-16 A role for accessory genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4 Golec, Piotr Wiczk, Aleksandra Majchrzyk, Anna Łoś, Joanna M. Węgrzyn, Grzegorz Łoś, Marcin Virus Genes Article Lysis inhibition (LIN) is a known feature of the T-even family of bacteriophages. Despite its historical role in the development of modern molecular genetics, many aspects of this phenomenon remain mostly unexplained. The key element of LIN is an interaction between two phage-encoded proteins, the T holin and the RI antiholin. This interaction is stabilized by RIII. In this report, we demonstrate the results of genetic experiments which suggest a synergistic action of two accessory proteins of bacteriophage T4, RI.-1, and RI.1 with RIII in the regulation of LIN. Springer US 2010-10-14 2010 /pmc/articles/PMC2962797/ /pubmed/20945083 http://dx.doi.org/10.1007/s11262-010-0532-1 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Golec, Piotr
Wiczk, Aleksandra
Majchrzyk, Anna
Łoś, Joanna M.
Węgrzyn, Grzegorz
Łoś, Marcin
A role for accessory genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4
title A role for accessory genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4
title_full A role for accessory genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4
title_fullStr A role for accessory genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4
title_full_unstemmed A role for accessory genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4
title_short A role for accessory genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4
title_sort role for accessory genes ri.-1 and ri.1 in the regulation of lysis inhibition by bacteriophage t4
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962797/
https://www.ncbi.nlm.nih.gov/pubmed/20945083
http://dx.doi.org/10.1007/s11262-010-0532-1
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