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Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives
Millions of patients worldwide suffer from end-stage liver pathologies, whose only curative therapy is liver transplantation (OLT). Given the donor organ shortage, alternatives to OLT have been evaluated, including cell therapies. Hepatocyte transplantation has been attempted to cure metabolic liver...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963137/ https://www.ncbi.nlm.nih.gov/pubmed/21048845 http://dx.doi.org/10.4061/2010/259461 |
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author | Piscaglia, Anna Chiara Campanale, Mariachiara Gasbarrini, Antonio Gasbarrini, Giovanni |
author_facet | Piscaglia, Anna Chiara Campanale, Mariachiara Gasbarrini, Antonio Gasbarrini, Giovanni |
author_sort | Piscaglia, Anna Chiara |
collection | PubMed |
description | Millions of patients worldwide suffer from end-stage liver pathologies, whose only curative therapy is liver transplantation (OLT). Given the donor organ shortage, alternatives to OLT have been evaluated, including cell therapies. Hepatocyte transplantation has been attempted to cure metabolic liver disorders and end-stage liver diseases. The evaluation of its efficacy is complicated by the shortage of human hepatocytes and their difficult expansion and cryopreservation. Recent advances in cell biology have led to the concept of “regenerative medicine”, based on the therapeutic potential of stem cells (SCs). Different types of SCs are theoretically eligible for liver cell replacement. These include embryonic and fetal SCs, induced pluripotent cells, annex SCs, endogenous liver SCs, and extrahepatic adult SCs. Aim of this paper is to critically analyze the possible sources of SCs suitable for liver repopulation and the results of the clinical trials that have been published until now. |
format | Text |
id | pubmed-2963137 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-29631372010-11-03 Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives Piscaglia, Anna Chiara Campanale, Mariachiara Gasbarrini, Antonio Gasbarrini, Giovanni Stem Cells Int Review Article Millions of patients worldwide suffer from end-stage liver pathologies, whose only curative therapy is liver transplantation (OLT). Given the donor organ shortage, alternatives to OLT have been evaluated, including cell therapies. Hepatocyte transplantation has been attempted to cure metabolic liver disorders and end-stage liver diseases. The evaluation of its efficacy is complicated by the shortage of human hepatocytes and their difficult expansion and cryopreservation. Recent advances in cell biology have led to the concept of “regenerative medicine”, based on the therapeutic potential of stem cells (SCs). Different types of SCs are theoretically eligible for liver cell replacement. These include embryonic and fetal SCs, induced pluripotent cells, annex SCs, endogenous liver SCs, and extrahepatic adult SCs. Aim of this paper is to critically analyze the possible sources of SCs suitable for liver repopulation and the results of the clinical trials that have been published until now. SAGE-Hindawi Access to Research 2010-09-01 /pmc/articles/PMC2963137/ /pubmed/21048845 http://dx.doi.org/10.4061/2010/259461 Text en Copyright © 2010 Anna Chiara Piscaglia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Piscaglia, Anna Chiara Campanale, Mariachiara Gasbarrini, Antonio Gasbarrini, Giovanni Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives |
title | Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives |
title_full | Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives |
title_fullStr | Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives |
title_full_unstemmed | Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives |
title_short | Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives |
title_sort | stem cell-based therapies for liver diseases: state of the art and new perspectives |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963137/ https://www.ncbi.nlm.nih.gov/pubmed/21048845 http://dx.doi.org/10.4061/2010/259461 |
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