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Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives

Millions of patients worldwide suffer from end-stage liver pathologies, whose only curative therapy is liver transplantation (OLT). Given the donor organ shortage, alternatives to OLT have been evaluated, including cell therapies. Hepatocyte transplantation has been attempted to cure metabolic liver...

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Autores principales: Piscaglia, Anna Chiara, Campanale, Mariachiara, Gasbarrini, Antonio, Gasbarrini, Giovanni
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963137/
https://www.ncbi.nlm.nih.gov/pubmed/21048845
http://dx.doi.org/10.4061/2010/259461
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author Piscaglia, Anna Chiara
Campanale, Mariachiara
Gasbarrini, Antonio
Gasbarrini, Giovanni
author_facet Piscaglia, Anna Chiara
Campanale, Mariachiara
Gasbarrini, Antonio
Gasbarrini, Giovanni
author_sort Piscaglia, Anna Chiara
collection PubMed
description Millions of patients worldwide suffer from end-stage liver pathologies, whose only curative therapy is liver transplantation (OLT). Given the donor organ shortage, alternatives to OLT have been evaluated, including cell therapies. Hepatocyte transplantation has been attempted to cure metabolic liver disorders and end-stage liver diseases. The evaluation of its efficacy is complicated by the shortage of human hepatocytes and their difficult expansion and cryopreservation. Recent advances in cell biology have led to the concept of “regenerative medicine”, based on the therapeutic potential of stem cells (SCs). Different types of SCs are theoretically eligible for liver cell replacement. These include embryonic and fetal SCs, induced pluripotent cells, annex SCs, endogenous liver SCs, and extrahepatic adult SCs. Aim of this paper is to critically analyze the possible sources of SCs suitable for liver repopulation and the results of the clinical trials that have been published until now.
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spelling pubmed-29631372010-11-03 Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives Piscaglia, Anna Chiara Campanale, Mariachiara Gasbarrini, Antonio Gasbarrini, Giovanni Stem Cells Int Review Article Millions of patients worldwide suffer from end-stage liver pathologies, whose only curative therapy is liver transplantation (OLT). Given the donor organ shortage, alternatives to OLT have been evaluated, including cell therapies. Hepatocyte transplantation has been attempted to cure metabolic liver disorders and end-stage liver diseases. The evaluation of its efficacy is complicated by the shortage of human hepatocytes and their difficult expansion and cryopreservation. Recent advances in cell biology have led to the concept of “regenerative medicine”, based on the therapeutic potential of stem cells (SCs). Different types of SCs are theoretically eligible for liver cell replacement. These include embryonic and fetal SCs, induced pluripotent cells, annex SCs, endogenous liver SCs, and extrahepatic adult SCs. Aim of this paper is to critically analyze the possible sources of SCs suitable for liver repopulation and the results of the clinical trials that have been published until now. SAGE-Hindawi Access to Research 2010-09-01 /pmc/articles/PMC2963137/ /pubmed/21048845 http://dx.doi.org/10.4061/2010/259461 Text en Copyright © 2010 Anna Chiara Piscaglia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Piscaglia, Anna Chiara
Campanale, Mariachiara
Gasbarrini, Antonio
Gasbarrini, Giovanni
Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives
title Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives
title_full Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives
title_fullStr Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives
title_full_unstemmed Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives
title_short Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives
title_sort stem cell-based therapies for liver diseases: state of the art and new perspectives
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963137/
https://www.ncbi.nlm.nih.gov/pubmed/21048845
http://dx.doi.org/10.4061/2010/259461
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