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Role of teriparatide in treatment of glucocorticoid-induced osteoporosis
Glucocorticoids are commonly used in various fields within medicine. One of their most common and clinically significant side effects is glucocorticoid-induced osteoporosis (GIOP). GIOP is a disease leading to progressive decreases in bone mineral density, decreased bone strength, and increased risk...
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963159/ https://www.ncbi.nlm.nih.gov/pubmed/21063460 http://dx.doi.org/10.2147/TCRM.S7776 |
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author | Lau, Arthur N Adachi, Jonathan D |
author_facet | Lau, Arthur N Adachi, Jonathan D |
author_sort | Lau, Arthur N |
collection | PubMed |
description | Glucocorticoids are commonly used in various fields within medicine. One of their most common and clinically significant side effects is glucocorticoid-induced osteoporosis (GIOP). GIOP is a disease leading to progressive decreases in bone mineral density, decreased bone strength, and increased risk of skeletal fractures. GIOP has a significant impact on the morbidity and health-related quality of life of the patients it affects. Glucocorticoids have deleterious effects on bone through promoting osteoblast apoptosis and inhibiting osteoblastogenesis. Teriparatide exerts anabolic effects on bone, so it is understandable why teriparatide is thought to be a rational treatment option. Clinical studies have indicated teriparatide is efficacious in the treatment of GIOP to improve bone mineral density values at the lumbar spine and femoral neck. Some evidence also suggests teriparatide may reduce rates of vertebral fractures in GIOP patients. Overall, this review of the current clinical evidence suggests teriparatide may be an efficacious and promising agent in the treatment of GIOP. |
format | Text |
id | pubmed-2963159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-29631592010-11-09 Role of teriparatide in treatment of glucocorticoid-induced osteoporosis Lau, Arthur N Adachi, Jonathan D Ther Clin Risk Manag Review Glucocorticoids are commonly used in various fields within medicine. One of their most common and clinically significant side effects is glucocorticoid-induced osteoporosis (GIOP). GIOP is a disease leading to progressive decreases in bone mineral density, decreased bone strength, and increased risk of skeletal fractures. GIOP has a significant impact on the morbidity and health-related quality of life of the patients it affects. Glucocorticoids have deleterious effects on bone through promoting osteoblast apoptosis and inhibiting osteoblastogenesis. Teriparatide exerts anabolic effects on bone, so it is understandable why teriparatide is thought to be a rational treatment option. Clinical studies have indicated teriparatide is efficacious in the treatment of GIOP to improve bone mineral density values at the lumbar spine and femoral neck. Some evidence also suggests teriparatide may reduce rates of vertebral fractures in GIOP patients. Overall, this review of the current clinical evidence suggests teriparatide may be an efficacious and promising agent in the treatment of GIOP. Dove Medical Press 2010-10-21 2010 /pmc/articles/PMC2963159/ /pubmed/21063460 http://dx.doi.org/10.2147/TCRM.S7776 Text en © 2010 Lau and Adachi, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Lau, Arthur N Adachi, Jonathan D Role of teriparatide in treatment of glucocorticoid-induced osteoporosis |
title | Role of teriparatide in treatment of glucocorticoid-induced osteoporosis |
title_full | Role of teriparatide in treatment of glucocorticoid-induced osteoporosis |
title_fullStr | Role of teriparatide in treatment of glucocorticoid-induced osteoporosis |
title_full_unstemmed | Role of teriparatide in treatment of glucocorticoid-induced osteoporosis |
title_short | Role of teriparatide in treatment of glucocorticoid-induced osteoporosis |
title_sort | role of teriparatide in treatment of glucocorticoid-induced osteoporosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963159/ https://www.ncbi.nlm.nih.gov/pubmed/21063460 http://dx.doi.org/10.2147/TCRM.S7776 |
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