Effect of Intrauterine Diabetes Exposure on the Incidence of End-Stage Renal Disease in Young Adults With Type 2 Diabetes

OBJECTIVE: We examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes. RESEARCH DESIGN AND METHODS: Individuals were followed from their first diabetic examination until December 2006, death, ESRD, o...

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Detalles Bibliográficos
Autores principales: Pavkov, Meda E., Hanson, Robert L., Knowler, William C., Sievers, Maurice L., Bennett, Peter H., Nelson, Robert G.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963501/
https://www.ncbi.nlm.nih.gov/pubmed/20693350
http://dx.doi.org/10.2337/dc10-0811
Descripción
Sumario:OBJECTIVE: We examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes. RESEARCH DESIGN AND METHODS: Individuals were followed from their first diabetic examination until December 2006, death, ESRD, or age of 45 years. RESULTS: Among the 1,850 diabetic participants, 102 had IDE. ESRD developed in 57, 5 of whom had IDE. Cumulative incidence of ESRD by age 45 was 19.3% in participants with IDE and 5.1% in those without; the age- and sex-adjusted incidence rate ratio was 4.12 (95% CI 1.54–11.02). After additional adjustment for age at diabetes onset, ESRD incidence was similar in the two groups (incidence rate ratio 1.38, 95% CI 0.45–4.24). CONCLUSIONS: IDE increases the age- and sex-adjusted incidence of ESRD fourfold in young adults with type 2 diabetes, mediated primarily by the earlier onset of type 2 diabetes in those with IDE.

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