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Pharmacological Vasodilation Improves Insulin-Stimulated Muscle Protein Anabolism but Not Glucose Utilization in Older Adults

OBJECTIVE: Skeletal muscle protein metabolism is resistant to the anabolic action of insulin in healthy, nondiabetic older adults. This defect is associated with impaired insulin-induced vasodilation and mTORC1 signaling. We hypothesized that, in older subjects, pharmacological restoration of insuli...

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Detalles Bibliográficos
Autores principales:	Timmerman, Kyle L., Lee, Jessica L., Fujita, Satoshi, Dhanani, Shaheen, Dreyer, Hans C., Fry, Christopher S., Drummond, Micah J., Sheffield-Moore, Melinda, Rasmussen, Blake B., Volpi, Elena
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963534/ https://www.ncbi.nlm.nih.gov/pubmed/20724580 http://dx.doi.org/10.2337/db10-0415

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