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Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

OBJECTIVE: Fibroblast growth factor 21 (FGF21) is a key mediator of fatty acid oxidation and lipid metabolism. Pharmacological doses of FGF21 improve glucose tolerance, lower serum free fatty acids, and lead to weight loss in obese mice. Surprisingly, however, FGF21 levels are elevated in obese ob/o...

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Detalles Bibliográficos
Autores principales:	Fisher, ffolliott M., Chui, Patricia C., Antonellis, Patrick J., Bina, Holly A., Kharitonenkov, Alexei, Flier, Jeffrey S., Maratos-Flier, Eleftheria
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963536/ https://www.ncbi.nlm.nih.gov/pubmed/20682689 http://dx.doi.org/10.2337/db10-0193

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