Posterior reversible encephalopathy syndrome in neuro-malaria

We report a case of a 37-year-old patient with Plasmodium falciparum infestation who developed posterior reversible encephalopathy. In cerebral malaria, microscopic studies have shown endothelial dysfunction and disruption of the blood–brain barrier. Data from the literature show that one of the mechanisms of posterior reversible encephalopathy may be capillary leakage and acute disruption of the blood–brain barrier. Our case supports the theory of blood–brain barrier disruption being a key factor in the causation of cerebral malaria.