AN OPEN STUDY OF CLOZAPINE IN THE TREATMENT OF RESISTANT SCHIZOPHRENIA

This open study was undertaken to assess the efficacy of clozapine in resistant schizophrenics, its side effects and safety profile and the mean dose required. Sample consisted of 28 patients who had been previously treated with neuroleptics and ECTs. A special proforma was prepared for recording th...

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Autores principales: Desai, Neena, Jain, Vani, Ghalsasi, Supriya, Dalvi, Madhusudan, Kelkar, Sejal
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963840/
https://www.ncbi.nlm.nih.gov/pubmed/21430808
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author Desai, Neena
Jain, Vani
Ghalsasi, Supriya
Dalvi, Madhusudan
Kelkar, Sejal
author_facet Desai, Neena
Jain, Vani
Ghalsasi, Supriya
Dalvi, Madhusudan
Kelkar, Sejal
author_sort Desai, Neena
collection PubMed
description This open study was undertaken to assess the efficacy of clozapine in resistant schizophrenics, its side effects and safety profile and the mean dose required. Sample consisted of 28 patients who had been previously treated with neuroleptics and ECTs. A special proforma was prepared for recording the psychopathology and side effect profile. The complete blood count, differential count and BPRS scores were recorded weekly for a period of 3 months. Within 1 month of treatment on a dose range of 100-200 mg/day a 25%-50% decline in the BPRS score was noticed, the mean dose required was 241 mg/day. Sedation and sialorrhoea constituted the commonest side effects in 90% patients. No case of agranulocytosis was reported. The implications of the study are discussed.
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spelling pubmed-29638402011-03-22 AN OPEN STUDY OF CLOZAPINE IN THE TREATMENT OF RESISTANT SCHIZOPHRENIA Desai, Neena Jain, Vani Ghalsasi, Supriya Dalvi, Madhusudan Kelkar, Sejal Indian J Psychiatry Original Article This open study was undertaken to assess the efficacy of clozapine in resistant schizophrenics, its side effects and safety profile and the mean dose required. Sample consisted of 28 patients who had been previously treated with neuroleptics and ECTs. A special proforma was prepared for recording the psychopathology and side effect profile. The complete blood count, differential count and BPRS scores were recorded weekly for a period of 3 months. Within 1 month of treatment on a dose range of 100-200 mg/day a 25%-50% decline in the BPRS score was noticed, the mean dose required was 241 mg/day. Sedation and sialorrhoea constituted the commonest side effects in 90% patients. No case of agranulocytosis was reported. The implications of the study are discussed. Medknow Publications 1999 /pmc/articles/PMC2963840/ /pubmed/21430808 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Desai, Neena
Jain, Vani
Ghalsasi, Supriya
Dalvi, Madhusudan
Kelkar, Sejal
AN OPEN STUDY OF CLOZAPINE IN THE TREATMENT OF RESISTANT SCHIZOPHRENIA
title AN OPEN STUDY OF CLOZAPINE IN THE TREATMENT OF RESISTANT SCHIZOPHRENIA
title_full AN OPEN STUDY OF CLOZAPINE IN THE TREATMENT OF RESISTANT SCHIZOPHRENIA
title_fullStr AN OPEN STUDY OF CLOZAPINE IN THE TREATMENT OF RESISTANT SCHIZOPHRENIA
title_full_unstemmed AN OPEN STUDY OF CLOZAPINE IN THE TREATMENT OF RESISTANT SCHIZOPHRENIA
title_short AN OPEN STUDY OF CLOZAPINE IN THE TREATMENT OF RESISTANT SCHIZOPHRENIA
title_sort open study of clozapine in the treatment of resistant schizophrenia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963840/
https://www.ncbi.nlm.nih.gov/pubmed/21430808
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