Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease

To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly chang...

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Detalles Bibliográficos
Autores principales: Nguyen, Huu Phuc, Björkqvist, Maria, Bode, Felix J., Stephan, Michael, von Hörsten, Stephan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Huntington Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964049/
https://www.ncbi.nlm.nih.gov/pubmed/20981129
http://dx.doi.org/10.1371/currents.RRN1190
Descripción
Sumario:To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.

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