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An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A

Myocardin-related transcription factors (MRTFs) are actin-regulated transcriptional coactivators, which bind G-actin through their N-terminal RPEL domains. In response to signal-induced actin polymerisation and concomitant G-actin depletion, MRTFs accumulate in the nucleus and activate target gene t...

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Detalles Bibliográficos
Autores principales:	Pawłowski, Rafał, Rajakylä, Eeva Kaisa, Vartiainen, Maria K, Treisman, Richard
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964165/ https://www.ncbi.nlm.nih.gov/pubmed/20818336 http://dx.doi.org/10.1038/emboj.2010.216

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