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Evolution of Bacterial Phosphoglycerate Mutases: Non-Homologous Isofunctional Enzymes Undergoing Gene Losses, Gains and Lateral Transfers

BACKGROUND: The glycolytic phosphoglycerate mutases exist as non-homologous isofunctional enzymes (NISE) having independent evolutionary origins and no similarity in primary sequence, 3D structure, or catalytic mechanism. Cofactor-dependent PGM (dPGM) requires 2,3-bisphosphoglycerate for activity; c...

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Detalles Bibliográficos
Autores principales:	Foster, Jeremy M., Davis, Paul J., Raverdy, Sylvine, Sibley, Marion H., Raleigh, Elisabeth A., Kumar, Sanjay, Carlow, Clotilde K. S.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964296/ https://www.ncbi.nlm.nih.gov/pubmed/21187861 http://dx.doi.org/10.1371/journal.pone.0013576

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