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The Human Host Defense Peptide LL-37 Interacts with Neisseria meningitidis Capsular Polysaccharides and Inhibits Inflammatory Mediators Release

Capsular polysaccharides (CPS) are a major virulence factor in meningococcal infections and form the basis for serogroup designation and protective vaccines. Our work has identified meningococcal CPS as a pro-inflammatory ligand that functions through TLR2 and TLR4-MD2-dependent activation. We hypot...

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Detalles Bibliográficos
Autores principales:	Zughaier, Susu M., Svoboda, Pavel, Pohl, Jan, Stephens, David S., Shafer, William M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964311/ https://www.ncbi.nlm.nih.gov/pubmed/21049021 http://dx.doi.org/10.1371/journal.pone.0013627

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