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Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts
The plant phytoalexin resveratrol was previously demonstrated to inhibit the differentiation and bone resorbing activity of osteoclasts, to promote the formation of osteoblasts from mesenchymal precursors in cultures, and inhibit myeloma cell proliferation, when used at high concentrations. In the c...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964465/ https://www.ncbi.nlm.nih.gov/pubmed/20842496 http://dx.doi.org/10.1007/s00223-010-9399-3 |
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author | Kupisiewicz, Katarzyna Boissy, Patrice Abdallah, Basem M. Hansen, Frederik Dagnaes Erben, Reinhold G. Savouret, Jean-Francois Søe, Kent Andersen, Thomas L. Plesner, Torben Delaisse, Jean-Marie |
author_facet | Kupisiewicz, Katarzyna Boissy, Patrice Abdallah, Basem M. Hansen, Frederik Dagnaes Erben, Reinhold G. Savouret, Jean-Francois Søe, Kent Andersen, Thomas L. Plesner, Torben Delaisse, Jean-Marie |
author_sort | Kupisiewicz, Katarzyna |
collection | PubMed |
description | The plant phytoalexin resveratrol was previously demonstrated to inhibit the differentiation and bone resorbing activity of osteoclasts, to promote the formation of osteoblasts from mesenchymal precursors in cultures, and inhibit myeloma cell proliferation, when used at high concentrations. In the current study, we screened five structurally modified resveratrol analogues for their ability to modify the differentiation of osteoclasts and osteoblasts and proliferation of myeloma cells. Compared to resveratrol, analogues showed an up to 5,000-fold increased potency to inhibit osteoclast differentiation. To a lesser extent, resveratrol analogues also promoted osteoblast maturation. However, they did not antagonize the proliferation of myeloma cells. The potency of the best-performing candidate in vitro was tested in vivo in an ovariectomy-induced model of osteoporosis, but an effect on bone loss could not be detected. Based on their powerful antiresorptive activity in vitro, resveratrol analogues might be attractive modulators of bone remodeling. However, further studies are required to establish their efficacy in vivo. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00223-010-9399-3) contains supplementary material, which is available to authorized users. |
format | Text |
id | pubmed-2964465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-29644652010-11-29 Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts Kupisiewicz, Katarzyna Boissy, Patrice Abdallah, Basem M. Hansen, Frederik Dagnaes Erben, Reinhold G. Savouret, Jean-Francois Søe, Kent Andersen, Thomas L. Plesner, Torben Delaisse, Jean-Marie Calcif Tissue Int Article The plant phytoalexin resveratrol was previously demonstrated to inhibit the differentiation and bone resorbing activity of osteoclasts, to promote the formation of osteoblasts from mesenchymal precursors in cultures, and inhibit myeloma cell proliferation, when used at high concentrations. In the current study, we screened five structurally modified resveratrol analogues for their ability to modify the differentiation of osteoclasts and osteoblasts and proliferation of myeloma cells. Compared to resveratrol, analogues showed an up to 5,000-fold increased potency to inhibit osteoclast differentiation. To a lesser extent, resveratrol analogues also promoted osteoblast maturation. However, they did not antagonize the proliferation of myeloma cells. The potency of the best-performing candidate in vitro was tested in vivo in an ovariectomy-induced model of osteoporosis, but an effect on bone loss could not be detected. Based on their powerful antiresorptive activity in vitro, resveratrol analogues might be attractive modulators of bone remodeling. However, further studies are required to establish their efficacy in vivo. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00223-010-9399-3) contains supplementary material, which is available to authorized users. Springer-Verlag 2010-09-15 2010 /pmc/articles/PMC2964465/ /pubmed/20842496 http://dx.doi.org/10.1007/s00223-010-9399-3 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Article Kupisiewicz, Katarzyna Boissy, Patrice Abdallah, Basem M. Hansen, Frederik Dagnaes Erben, Reinhold G. Savouret, Jean-Francois Søe, Kent Andersen, Thomas L. Plesner, Torben Delaisse, Jean-Marie Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts |
title | Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts |
title_full | Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts |
title_fullStr | Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts |
title_full_unstemmed | Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts |
title_short | Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts |
title_sort | potential of resveratrol analogues as antagonists of osteoclasts and promoters of osteoblasts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964465/ https://www.ncbi.nlm.nih.gov/pubmed/20842496 http://dx.doi.org/10.1007/s00223-010-9399-3 |
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