Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

Foxp3-expressing regulatory T (T reg) cells have been implicated in parasite-driven inhibition of host immunity during chronic infection. We addressed whether parasites can directly induce T reg cells. Foxp3 expression was stimulated in naive Foxp3(−) T cells in mice infected with the intestinal hel...

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Detalles Bibliográficos
Autores principales: Grainger, John R., Smith, Katie A., Hewitson, James P., McSorley, Henry J., Harcus, Yvonne, Filbey, Kara J., Finney, Constance A.M., Greenwood, Edward J.D., Knox, David P., Wilson, Mark S., Belkaid, Yasmine, Rudensky, Alexander Y., Maizels, Rick M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964568/
https://www.ncbi.nlm.nih.gov/pubmed/20876311
http://dx.doi.org/10.1084/jem.20101074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964568/
https://www.ncbi.nlm.nih.gov/pubmed/20876311
http://dx.doi.org/10.1084/jem.20101074

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