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Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis

Cyclin-dependent kinase 5 (Cdk5) is a ubiquitously expressed serine/threonine kinase. However, a requirement for Cdk5 has been demonstrated only in postmitotic neurons where there is abundant expression of its activating partners p35 and/or p39. Although hyperactivation of the Cdk5–p35 complex has b...

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Detalles Bibliográficos
Autores principales:	Pareek, Tej K., Lam, Eric, Zheng, Xiaojing, Askew, David, Kulkarni, Ashok B., Chance, Mark R., Huang, Alex Y., Cooke, Kenneth R., Letterio, John J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964575/ https://www.ncbi.nlm.nih.gov/pubmed/20937706 http://dx.doi.org/10.1084/jem.20100876

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