The innate immune system in host mice targets cells with allogenic mitochondrial DNA

Mitochondrial DNA (mtDNA) has been proposed to be involved in respiratory function, and mtDNA mutations have been associated with aging, tumors, and various disorders, but the effects of mtDNA imported into transplants from different individuals or aged subjects have been unclear. We examined this i...

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Autores principales: Ishikawa, Kaori, Toyama-Sorimachi, Noriko, Nakada, Kazuto, Morimoto, Mami, Imanishi, Hirotake, Yoshizaki, Mariko, Sasawatari, Shigemi, Niikura, Mamoru, Takenaga, Keizo, Yonekawa, Hiromichi, Hayashi, Jun-Ichi
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964578/
https://www.ncbi.nlm.nih.gov/pubmed/20937705
http://dx.doi.org/10.1084/jem.20092296
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author Ishikawa, Kaori
Toyama-Sorimachi, Noriko
Nakada, Kazuto
Morimoto, Mami
Imanishi, Hirotake
Yoshizaki, Mariko
Sasawatari, Shigemi
Niikura, Mamoru
Takenaga, Keizo
Yonekawa, Hiromichi
Hayashi, Jun-Ichi
author_facet Ishikawa, Kaori
Toyama-Sorimachi, Noriko
Nakada, Kazuto
Morimoto, Mami
Imanishi, Hirotake
Yoshizaki, Mariko
Sasawatari, Shigemi
Niikura, Mamoru
Takenaga, Keizo
Yonekawa, Hiromichi
Hayashi, Jun-Ichi
author_sort Ishikawa, Kaori
collection PubMed
description Mitochondrial DNA (mtDNA) has been proposed to be involved in respiratory function, and mtDNA mutations have been associated with aging, tumors, and various disorders, but the effects of mtDNA imported into transplants from different individuals or aged subjects have been unclear. We examined this issue by generating trans-mitochondrial tumor cells and embryonic stem cells that shared the syngenic C57BL/6 (B6) strain–derived nuclear DNA background but possessed mtDNA derived from allogenic mouse strains. We demonstrate that transplants with mtDNA from the NZB/B1NJ strain were rejected from the host B6 mice, not by the acquired immune system but by the innate immune system. This rejection was caused partly by NK cells and involved a MyD88-dependent pathway. These results introduce novel roles of mtDNA and innate immunity in tumor immunology and transplantation medicine.
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spelling pubmed-29645782011-04-25 The innate immune system in host mice targets cells with allogenic mitochondrial DNA Ishikawa, Kaori Toyama-Sorimachi, Noriko Nakada, Kazuto Morimoto, Mami Imanishi, Hirotake Yoshizaki, Mariko Sasawatari, Shigemi Niikura, Mamoru Takenaga, Keizo Yonekawa, Hiromichi Hayashi, Jun-Ichi J Exp Med Brief Definitive Report Mitochondrial DNA (mtDNA) has been proposed to be involved in respiratory function, and mtDNA mutations have been associated with aging, tumors, and various disorders, but the effects of mtDNA imported into transplants from different individuals or aged subjects have been unclear. We examined this issue by generating trans-mitochondrial tumor cells and embryonic stem cells that shared the syngenic C57BL/6 (B6) strain–derived nuclear DNA background but possessed mtDNA derived from allogenic mouse strains. We demonstrate that transplants with mtDNA from the NZB/B1NJ strain were rejected from the host B6 mice, not by the acquired immune system but by the innate immune system. This rejection was caused partly by NK cells and involved a MyD88-dependent pathway. These results introduce novel roles of mtDNA and innate immunity in tumor immunology and transplantation medicine. The Rockefeller University Press 2010-10-25 /pmc/articles/PMC2964578/ /pubmed/20937705 http://dx.doi.org/10.1084/jem.20092296 Text en © 2010 Ishikawa et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Brief Definitive Report
Ishikawa, Kaori
Toyama-Sorimachi, Noriko
Nakada, Kazuto
Morimoto, Mami
Imanishi, Hirotake
Yoshizaki, Mariko
Sasawatari, Shigemi
Niikura, Mamoru
Takenaga, Keizo
Yonekawa, Hiromichi
Hayashi, Jun-Ichi
The innate immune system in host mice targets cells with allogenic mitochondrial DNA
title The innate immune system in host mice targets cells with allogenic mitochondrial DNA
title_full The innate immune system in host mice targets cells with allogenic mitochondrial DNA
title_fullStr The innate immune system in host mice targets cells with allogenic mitochondrial DNA
title_full_unstemmed The innate immune system in host mice targets cells with allogenic mitochondrial DNA
title_short The innate immune system in host mice targets cells with allogenic mitochondrial DNA
title_sort innate immune system in host mice targets cells with allogenic mitochondrial dna
topic Brief Definitive Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964578/
https://www.ncbi.nlm.nih.gov/pubmed/20937705
http://dx.doi.org/10.1084/jem.20092296
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