Cargando…

Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak-Stat signaling and inhibits HCV RNA replication

Interferon alpha (IFN-α) binds to a cell surface receptor that activates the Jak-Stat signaling pathway. A critical component of this pathway is the translocation of interferon stimulated gene factor 3 (a complex of three proteins Stat1, Stat2 and IRF9) to the nucleus to activate antiviral genes. A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Poat, Bret, Hazari, Sidhartha, Chandra, Partha K, Gunduz, Feyza, Alvarez, Xavier, Balart, Luis A, Garry, Robert F, Dash, Srikanta
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964675/ https://www.ncbi.nlm.nih.gov/pubmed/20939906 http://dx.doi.org/10.1186/1743-422X-7-265

Ejemplares similares

SH2 Modified STAT1 Induces HLA-I Expression and Improves IFN-γ Signaling in IFN-α Resistant HCV Replicon Cells
por: Poat, Bret, et al.
Publicado: (2010)

Correction: SH2 Modified STAT1 Induces HLA-I Expression and Improves IFN-γ Signaling in IFN-α Resistant HCV Replicon Cells
por: Poat, Bret, et al.
Publicado: (2010)

Impaired antiviral activity of interferon alpha against hepatitis C virus 2a in Huh-7 cells with a defective Jak-Stat pathway
por: Hazari, Sidhartha, et al.
Publicado: (2010)

Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1
por: Datta, Sibnarayan, et al.
Publicado: (2011)

Free fatty acids induce ER stress and block antiviral activity of interferon alpha against hepatitis C virus in cell culture
por: Gunduz, Feyza, et al.
Publicado: (2012)

Intracytoplasmic stable expression of IgG1 antibody targeting NS3 helicase inhibits replication of highly efficient hepatitis C Virus 2a clone
por: Chandra, Partha K, et al.
Publicado: (2010)

Impaired Expression of Type I and Type II Interferon Receptors in HCV-Associated Chronic Liver Disease and Liver Cirrhosis
por: Chandra, Partha K., et al.
Publicado: (2014)

IFN-λ Inhibits MiR-122 Transcription through a Stat3-HNF4α Inflammatory Feedback Loop in an IFN-α Resistant HCV Cell Culture System
por: Aboulnasr, Fatma, et al.
Publicado: (2015)

Interferon and Ribavirin Combination Treatment Synergistically Inhibit HCV Internal Ribosome Entry Site Mediated Translation at the Level of Polyribosome Formation
por: Panigrahi, Rajesh, et al.
Publicado: (2013)

Reduced expression of Jak-1 and Tyk-2 proteins leads to interferon resistance in Hepatitis C virus replicon
por: Hazari, Sidhartha, et al.
Publicado: (2007)

JAKs and STATs in chemoresistance
por: Costa-Pereira, Ana P
Publicado: (2010)

JAK-STAT and feeding
por: Ladyman, Sharon R., et al.
Publicado: (2013)

Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways
por: Czerkies, Maciej, et al.
Publicado: (2018)

Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway
por: Au-Yeung, Nancy, et al.
Publicado: (2013)

TNF-Mediated Inhibition of Classical Swine Fever Virus Replication Is IRF1-, NF-κB- and JAK/STAT Signaling-Dependent
por: Liniger, Matthias, et al.
Publicado: (2021)

A JAK/STAT invasion
por: Wells, William A.
Publicado: (2002)

JAK-STAT and bone metabolism
por: Li, Jiliang
Publicado: (2013)

The Drosophila JAK-STAT pathway
por: Zeidler, Martin P, et al.
Publicado: (2013)

Evolution of the JAK-STAT pathway
por: Liongue, Clifford, et al.
Publicado: (2013)

The JAK-STAT pathway at 20
por: Darnell, Jr., James E.
Publicado: (2012)

JAK-STAT in lymphoproliferative disorders
por: Rabadan, Raul, et al.
Publicado: (2015)

Expression of JAK3, STAT2, STAT4, and STAT6 in pemphigus vulgaris
por: Juczynska, K., et al.
Publicado: (2020)

Chaperone-Mediated Autophagy Targets IFNAR1 for Lysosomal Degradation in Free Fatty Acid Treated HCV Cell Culture
por: Kurt, Ramazan, et al.
Publicado: (2015)

JAK-STAT in heterochromatin and genome stability
por: Silver-Morse, Louise, et al.
Publicado: (2013)

JAK-STAT and intestinal mucosal immunology
por: Heneghan, Aaron F, et al.
Publicado: (2013)

JAK-STAT: Getting to the heart of the matter
por: Barry, Sean P.
Publicado: (2012)

JAK-STAT pathway and myogenic differentiation
por: Jang, You-Na, et al.
Publicado: (2013)

JAK-STAT Signalling Pathway in Cancer
por: Brooks, Andrew J., et al.
Publicado: (2020)

JAK/STAT signaling in hepatocellular carcinoma
por: Hin Tang, Justin Jit, et al.
Publicado: (2020)

JAK-STAT in Early Hematopoiesis and Leukemia
por: Fasouli, Eirini Sofia, et al.
Publicado: (2021)

JAK-STAT pathway inhibitors in dermatology()
por: Miot, Hélio Amante, et al.
Publicado: (2023)

An overview of JAK/STAT pathways and JAK inhibition in alopecia areata
por: Lensing, Maddison, et al.
Publicado: (2022)

Jak2-Independent Activation of Stat3 by Intracellular Angiotensin II in Human Mesangial Cells
por: Singh, Rekha
Publicado: (2011)

Protein Inhibitor of Activated STAT (PIAS) Negatively Regulates the JAK/STAT Pathway by Inhibiting STAT Phosphorylation and Translocation
por: Niu, Guo-Juan, et al.
Publicado: (2018)

Properties of STAT1 and IRF1 enhancers and the influence of SNPs
por: Abou El Hassan, Mohamed, et al.
Publicado: (2017)

Lac water extract inhibits IFN-γ signaling through JAK2-STAT1-IRF1 axis in human melanoma
por: Li, Luhui, et al.
Publicado: (2018)

JAK/STAT Pathway Mutations in T-ALL, Including the STAT5B N642H Mutation, are Sensitive to JAK1/JAK3 Inhibitors
por: Govaerts, Inge, et al.
Publicado: (2019)

The JAK/STAT Pathway Is Involved in Synaptic Plasticity
por: Nicolas, Céline S., et al.
Publicado: (2012)

JAK/STAT signaling and human in vitro myogenesis
por: Trenerry, Marissa K, et al.
Publicado: (2011)

JAK-STAT signaling and myocardial glucose metabolism
por: Frias, Miguel A, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_p09f9mk7umm6ie5rimk6rpsiua