Cargando…

NATRIURETIC PEPTIDE SYSTEM AND CARDIOVASCULAR DISEASE

The mammalian Natriuretic Peptide (NP) system consists of neuro-hormones, such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), c-type natriuretic peptide (CNP), and the N-Terminal fragment of BNP (NT-pro-BNP). In response to some cardiovascular derangement the heart (acting as...

Descripción completa

Detalles Bibliográficos
Autor principal: Federico, Cacciapuoti
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964706/
https://www.ncbi.nlm.nih.gov/pubmed/21042458
_version_ 1782189416546041856
author Federico, Cacciapuoti
author_facet Federico, Cacciapuoti
author_sort Federico, Cacciapuoti
collection PubMed
description The mammalian Natriuretic Peptide (NP) system consists of neuro-hormones, such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), c-type natriuretic peptide (CNP), and the N-Terminal fragment of BNP (NT-pro-BNP). In response to some cardiovascular derangement the heart (acting as an endocrine organ), brain and other structures secretes natriuretic peptides in an attempt to restore normal circulatory conditions. Their actions are modulated through membrane-bound guanylyl cyclased (GC) receptors. They induce diuresis, natriuresis and vasodilation in the presence of congestive heart failure. These neuro-hormones also play a role in the suppression of neointimal formation after vascular injury. In addition, they act as antifibrotic and antihypertrophic agents preventing cardiac remodeling after myocardial infarction. Further, NP have diagnostic and prognostic role in heart failure, vasoconstriction, left ventricular late remodeling after MI and others. At present, some drugs such as Nesiritide, NEP inhibitors and vasopeptidase inhibitors were synthetized from NP, to antagonize these cardiovascular derengements. In future, it will be possibile to elaborate some drugs similar to petidase inhibitors and some CNP-like drugs able to reduce many symptoms of cardiovascular derangements without significant side effects.
format Text
id pubmed-2964706
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Medknow Publications
record_format MEDLINE/PubMed
spelling pubmed-29647062010-11-01 NATRIURETIC PEPTIDE SYSTEM AND CARDIOVASCULAR DISEASE Federico, Cacciapuoti Heart Views Review Article The mammalian Natriuretic Peptide (NP) system consists of neuro-hormones, such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), c-type natriuretic peptide (CNP), and the N-Terminal fragment of BNP (NT-pro-BNP). In response to some cardiovascular derangement the heart (acting as an endocrine organ), brain and other structures secretes natriuretic peptides in an attempt to restore normal circulatory conditions. Their actions are modulated through membrane-bound guanylyl cyclased (GC) receptors. They induce diuresis, natriuresis and vasodilation in the presence of congestive heart failure. These neuro-hormones also play a role in the suppression of neointimal formation after vascular injury. In addition, they act as antifibrotic and antihypertrophic agents preventing cardiac remodeling after myocardial infarction. Further, NP have diagnostic and prognostic role in heart failure, vasoconstriction, left ventricular late remodeling after MI and others. At present, some drugs such as Nesiritide, NEP inhibitors and vasopeptidase inhibitors were synthetized from NP, to antagonize these cardiovascular derengements. In future, it will be possibile to elaborate some drugs similar to petidase inhibitors and some CNP-like drugs able to reduce many symptoms of cardiovascular derangements without significant side effects. Medknow Publications 2010 /pmc/articles/PMC2964706/ /pubmed/21042458 Text en © Gulf Heart Association http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Federico, Cacciapuoti
NATRIURETIC PEPTIDE SYSTEM AND CARDIOVASCULAR DISEASE
title NATRIURETIC PEPTIDE SYSTEM AND CARDIOVASCULAR DISEASE
title_full NATRIURETIC PEPTIDE SYSTEM AND CARDIOVASCULAR DISEASE
title_fullStr NATRIURETIC PEPTIDE SYSTEM AND CARDIOVASCULAR DISEASE
title_full_unstemmed NATRIURETIC PEPTIDE SYSTEM AND CARDIOVASCULAR DISEASE
title_short NATRIURETIC PEPTIDE SYSTEM AND CARDIOVASCULAR DISEASE
title_sort natriuretic peptide system and cardiovascular disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964706/
https://www.ncbi.nlm.nih.gov/pubmed/21042458
work_keys_str_mv AT federicocacciapuoti natriureticpeptidesystemandcardiovasculardisease