ACTIVE PLATELET 5-HT UPTAKE IN DEPRESSIVES TREATED WITH IMPRAMINE AND ECT

Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patient...

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Detalles Bibliográficos
Autores principales: Dalal, P.K., Lal, Narottam, Trivedi, J.K., Seth, P.K., Agarwal, A.K., Khalid, Abdul
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1998
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964820/
https://www.ncbi.nlm.nih.gov/pubmed/21494445
Descripción
Sumario:Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patients of major depression and equal number of age and sex-matched controls were included in the study. The depressives received imipramine (N=15) or ECT (N=15). Pretreatment active platelet 5-HT uptake was lower in depressives. Treatment with imipramine resulted in significant decrease in 5-HT uptake while with ECT there was significant increase. The serotonergic mechanisms are discussed.

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