ACTIVE PLATELET 5-HT UPTAKE IN DEPRESSIVES TREATED WITH IMPRAMINE AND ECT

Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patient...

Descripción completa

Detalles Bibliográficos
Autores principales: Dalal, P.K., Lal, Narottam, Trivedi, J.K., Seth, P.K., Agarwal, A.K., Khalid, Abdul
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1998
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964820/
https://www.ncbi.nlm.nih.gov/pubmed/21494445
_version_ 1782189443162046464
author Dalal, P.K.
Lal, Narottam
Trivedi, J.K.
Seth, P.K.
Agarwal, A.K.
Khalid, Abdul
author_facet Dalal, P.K.
Lal, Narottam
Trivedi, J.K.
Seth, P.K.
Agarwal, A.K.
Khalid, Abdul
author_sort Dalal, P.K.
collection PubMed
description Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patients of major depression and equal number of age and sex-matched controls were included in the study. The depressives received imipramine (N=15) or ECT (N=15). Pretreatment active platelet 5-HT uptake was lower in depressives. Treatment with imipramine resulted in significant decrease in 5-HT uptake while with ECT there was significant increase. The serotonergic mechanisms are discussed.
format Text
id pubmed-2964820
institution National Center for Biotechnology Information
language English
publishDate 1998
publisher Medknow Publications
record_format MEDLINE/PubMed
spelling pubmed-29648202011-04-14 ACTIVE PLATELET 5-HT UPTAKE IN DEPRESSIVES TREATED WITH IMPRAMINE AND ECT Dalal, P.K. Lal, Narottam Trivedi, J.K. Seth, P.K. Agarwal, A.K. Khalid, Abdul Indian J Psychiatry Original Article Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patients of major depression and equal number of age and sex-matched controls were included in the study. The depressives received imipramine (N=15) or ECT (N=15). Pretreatment active platelet 5-HT uptake was lower in depressives. Treatment with imipramine resulted in significant decrease in 5-HT uptake while with ECT there was significant increase. The serotonergic mechanisms are discussed. Medknow Publications 1998 /pmc/articles/PMC2964820/ /pubmed/21494445 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Dalal, P.K.
Lal, Narottam
Trivedi, J.K.
Seth, P.K.
Agarwal, A.K.
Khalid, Abdul
ACTIVE PLATELET 5-HT UPTAKE IN DEPRESSIVES TREATED WITH IMPRAMINE AND ECT
title ACTIVE PLATELET 5-HT UPTAKE IN DEPRESSIVES TREATED WITH IMPRAMINE AND ECT
title_full ACTIVE PLATELET 5-HT UPTAKE IN DEPRESSIVES TREATED WITH IMPRAMINE AND ECT
title_fullStr ACTIVE PLATELET 5-HT UPTAKE IN DEPRESSIVES TREATED WITH IMPRAMINE AND ECT
title_full_unstemmed ACTIVE PLATELET 5-HT UPTAKE IN DEPRESSIVES TREATED WITH IMPRAMINE AND ECT
title_short ACTIVE PLATELET 5-HT UPTAKE IN DEPRESSIVES TREATED WITH IMPRAMINE AND ECT
title_sort active platelet 5-ht uptake in depressives treated with impramine and ect
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964820/
https://www.ncbi.nlm.nih.gov/pubmed/21494445
work_keys_str_mv AT dalalpk activeplatelet5htuptakeindepressivestreatedwithimpramineandect
AT lalnarottam activeplatelet5htuptakeindepressivestreatedwithimpramineandect
AT trivedijk activeplatelet5htuptakeindepressivestreatedwithimpramineandect
AT sethpk activeplatelet5htuptakeindepressivestreatedwithimpramineandect
AT agarwalak activeplatelet5htuptakeindepressivestreatedwithimpramineandect
AT khalidabdul activeplatelet5htuptakeindepressivestreatedwithimpramineandect

Ejemplares similares