REFRACTORY SCHIZOPHRENIA, CLOZAPINE AND EPILEPSY : MANAGEMENT STRATEGIES

This case of refractory schizophrenia in a 28 year old male showed significant improvement with clozapine. But therapeutic doses of clozapine were associated with generalised tonic clonic seizures (GTCS). Addition of sodium valproate allowed adequate control of schizophrenic symptoms as well as seiz...

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Detalles Bibliográficos
Autores principales: Guha, Prathama, Nizamie, Haque S.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1998
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964825/
https://www.ncbi.nlm.nih.gov/pubmed/21494450
Descripción
Sumario:This case of refractory schizophrenia in a 28 year old male showed significant improvement with clozapine. But therapeutic doses of clozapine were associated with generalised tonic clonic seizures (GTCS). Addition of sodium valproate allowed adequate control of schizophrenic symptoms as well as seizures. EEG abnormality correlated surprisingly well with development of GTCS and subsequent improvement with anticonvulsant. Factors that lead to seizure-vulnerability in clozapine treated patients are discussed.

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