REFRACTORY SCHIZOPHRENIA, CLOZAPINE AND EPILEPSY : MANAGEMENT STRATEGIES

This case of refractory schizophrenia in a 28 year old male showed significant improvement with clozapine. But therapeutic doses of clozapine were associated with generalised tonic clonic seizures (GTCS). Addition of sodium valproate allowed adequate control of schizophrenic symptoms as well as seiz...

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Detalles Bibliográficos
Autores principales: Guha, Prathama, Nizamie, Haque S.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1998
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964825/
https://www.ncbi.nlm.nih.gov/pubmed/21494450
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author Guha, Prathama
Nizamie, Haque S.
author_facet Guha, Prathama
Nizamie, Haque S.
author_sort Guha, Prathama
collection PubMed
description This case of refractory schizophrenia in a 28 year old male showed significant improvement with clozapine. But therapeutic doses of clozapine were associated with generalised tonic clonic seizures (GTCS). Addition of sodium valproate allowed adequate control of schizophrenic symptoms as well as seizures. EEG abnormality correlated surprisingly well with development of GTCS and subsequent improvement with anticonvulsant. Factors that lead to seizure-vulnerability in clozapine treated patients are discussed.
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spelling pubmed-29648252011-04-14 REFRACTORY SCHIZOPHRENIA, CLOZAPINE AND EPILEPSY : MANAGEMENT STRATEGIES Guha, Prathama Nizamie, Haque S. Indian J Psychiatry Case Report This case of refractory schizophrenia in a 28 year old male showed significant improvement with clozapine. But therapeutic doses of clozapine were associated with generalised tonic clonic seizures (GTCS). Addition of sodium valproate allowed adequate control of schizophrenic symptoms as well as seizures. EEG abnormality correlated surprisingly well with development of GTCS and subsequent improvement with anticonvulsant. Factors that lead to seizure-vulnerability in clozapine treated patients are discussed. Medknow Publications 1998 /pmc/articles/PMC2964825/ /pubmed/21494450 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Guha, Prathama
Nizamie, Haque S.
REFRACTORY SCHIZOPHRENIA, CLOZAPINE AND EPILEPSY : MANAGEMENT STRATEGIES
title REFRACTORY SCHIZOPHRENIA, CLOZAPINE AND EPILEPSY : MANAGEMENT STRATEGIES
title_full REFRACTORY SCHIZOPHRENIA, CLOZAPINE AND EPILEPSY : MANAGEMENT STRATEGIES
title_fullStr REFRACTORY SCHIZOPHRENIA, CLOZAPINE AND EPILEPSY : MANAGEMENT STRATEGIES
title_full_unstemmed REFRACTORY SCHIZOPHRENIA, CLOZAPINE AND EPILEPSY : MANAGEMENT STRATEGIES
title_short REFRACTORY SCHIZOPHRENIA, CLOZAPINE AND EPILEPSY : MANAGEMENT STRATEGIES
title_sort refractory schizophrenia, clozapine and epilepsy : management strategies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964825/
https://www.ncbi.nlm.nih.gov/pubmed/21494450
work_keys_str_mv AT guhaprathama refractoryschizophreniaclozapineandepilepsymanagementstrategies
AT nizamiehaques refractoryschizophreniaclozapineandepilepsymanagementstrategies

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