PAFc, a Key Player in MLL-rearranged Leukemogenesis

Recent studies identified an interaction between the Polymerase Associated Factor complex (PAFc) and Mixed Lineage Leukemia (MLL), including MLLrearranged oncoproteins. This interaction is critical for MLL transcriptional activity and MLL-rearranged leukemogenesis. Here, we discuss the potential mol...

Descripción completa

Detalles Bibliográficos
Autores principales: Tan, Jiaying, Muntean, Andrew G., Hess, Jay L.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965052/
https://www.ncbi.nlm.nih.gov/pubmed/21037944
_version_ 1782189464098963456
author Tan, Jiaying
Muntean, Andrew G.
Hess, Jay L.
author_facet Tan, Jiaying
Muntean, Andrew G.
Hess, Jay L.
author_sort Tan, Jiaying
collection PubMed
description Recent studies identified an interaction between the Polymerase Associated Factor complex (PAFc) and Mixed Lineage Leukemia (MLL), including MLLrearranged oncoproteins. This interaction is critical for MLL transcriptional activity and MLL-rearranged leukemogenesis. Here, we discuss the potential molecular role of the PAFc in transcriptional dysregulation of MLL target genes and the interplay between PAFc and MLL-rearranged oncoproteins in leukemogenesis.
format Text
id pubmed-2965052
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-29650522010-10-27 PAFc, a Key Player in MLL-rearranged Leukemogenesis Tan, Jiaying Muntean, Andrew G. Hess, Jay L. Oncotarget Research Perspectives Recent studies identified an interaction between the Polymerase Associated Factor complex (PAFc) and Mixed Lineage Leukemia (MLL), including MLLrearranged oncoproteins. This interaction is critical for MLL transcriptional activity and MLL-rearranged leukemogenesis. Here, we discuss the potential molecular role of the PAFc in transcriptional dysregulation of MLL target genes and the interplay between PAFc and MLL-rearranged oncoproteins in leukemogenesis. Impact Journals LLC 2010-10-05 /pmc/articles/PMC2965052/ /pubmed/21037944 Text en Copyright: © 2010 Tan et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspectives
Tan, Jiaying
Muntean, Andrew G.
Hess, Jay L.
PAFc, a Key Player in MLL-rearranged Leukemogenesis
title PAFc, a Key Player in MLL-rearranged Leukemogenesis
title_full PAFc, a Key Player in MLL-rearranged Leukemogenesis
title_fullStr PAFc, a Key Player in MLL-rearranged Leukemogenesis
title_full_unstemmed PAFc, a Key Player in MLL-rearranged Leukemogenesis
title_short PAFc, a Key Player in MLL-rearranged Leukemogenesis
title_sort pafc, a key player in mll-rearranged leukemogenesis
topic Research Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965052/
https://www.ncbi.nlm.nih.gov/pubmed/21037944
work_keys_str_mv AT tanjiaying pafcakeyplayerinmllrearrangedleukemogenesis
AT munteanandrewg pafcakeyplayerinmllrearrangedleukemogenesis
AT hessjayl pafcakeyplayerinmllrearrangedleukemogenesis

Ejemplares similares