Identification and Characterization of a Leucine-Rich Repeat Kinase 2 (LRRK2) Consensus Phosphorylation Motif

Mutations in LRRK2 (leucine-rich repeat kinase 2) have been identified as major genetic determinants of Parkinson's disease (PD). The most prevalent mutation, G2019S, increases LRRK2's kinase activity, therefore understanding the sites and substrates that LRRK2 phosphorylates is critical t...

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Detalles Bibliográficos
Autores principales: Pungaliya, Pooja P., Bai, Yuchen, Lipinski, Kerri, Anand, Vasanti S., Sen, Saurabh, Brown, Eugene L., Bates, Brian, Reinhart, Peter H., West, Andrew B., Hirst, Warren D., Braithwaite, Steven P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965117/
https://www.ncbi.nlm.nih.gov/pubmed/21060682
http://dx.doi.org/10.1371/journal.pone.0013672

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