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Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts

In eukaryotic cells, the Rad6/Rad18-dependent monoubiquitination of the proliferating cell nuclear antigen (PCNA) plays an essential role in the switching between replication and translesion DNA synthesis (TLS). The DNA polymerase Polη binds to PCNA via a consensus C-terminal PCNA-interacting protei...

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Detalles Bibliográficos
Autores principales:	Schmutz, Valérie, Janel-Bintz, Régine, Wagner, Jérôme, Biard, Denis, Shiomi, Naoko, Fuchs, Robert P., Cordonnier, Agnès M.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965212/ https://www.ncbi.nlm.nih.gov/pubmed/20529881 http://dx.doi.org/10.1093/nar/gkq403

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