Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors

Several different approaches exist to generate expressed RNA interference (RNAi) precursors for multiple target inhibition, a strategy referred to as combinatorial (co)RNAi. One such approach makes use of RNA Pol III-expressed long hairpin RNAs (lhRNAs), which are processed by Dicer to generate mult...

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Detalles Bibliográficos
Autores principales: Saayman, Sheena, Arbuthnot, Patrick, Weinberg, Marc S.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965221/
https://www.ncbi.nlm.nih.gov/pubmed/20525791
http://dx.doi.org/10.1093/nar/gkq460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965221/
https://www.ncbi.nlm.nih.gov/pubmed/20525791
http://dx.doi.org/10.1093/nar/gkq460

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