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A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer

Lymphoid enhancer factor 1 (LEF-1) mediates Wnt signaling via recruitment of β-catenin to target genes. The LEF1 gene is aberrantly transcribed in colon cancers because promoter 1 (P1) is a Wnt target gene and is activated by TCF–β-catenin complexes. A second promoter in intron 2 (P2) produces domin...

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Detalles Bibliográficos
Autores principales:	Yokoyama, Noriko N., Pate, Kira T., Sprowl, Stephanie, Waterman, Marian L.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965227/ https://www.ncbi.nlm.nih.gov/pubmed/20525792 http://dx.doi.org/10.1093/nar/gkq492

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