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Divergent β-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3
Human AlkB homologues ABH2 and ABH3 repair 1-methyladenine and 3-methylcytosine in DNA/RNA by oxidative demethylation. The enzymes have similar overall folds and active sites, but are functionally divergent. ABH2 efficiently demethylates both single- and double-stranded (ds) DNA, whereas ABH3 has a...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965238/ https://www.ncbi.nlm.nih.gov/pubmed/20525795 http://dx.doi.org/10.1093/nar/gkq518 |