Insights into the DNA stabilizing contributions of a bicyclic cytosine analogue: crystal structures of DNA duplexes containing 7,8-dihydropyrido [2,3-d]pyrimidin-2-one

The incorporation of the bicyclic cytosine analogue 7,8-dihydropyrido[2,3-d]pyrimidin-2-one (X) into DNA duplexes results in a significant enhancement of their stability (3–4 K per modification). To establish the effects of X on the local hydrogen-bonding and base stacking interactions and the overa...

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Detalles Bibliográficos
Autores principales: Magat Juan, Ella Czarina, Shimizu, Satoru, Ma, Xiao, Kurose, Taizo, Haraguchi, Tsuyoshi, Zhang, Fang, Tsunoda, Masaru, Ohkubo, Akihiro, Sekine, Mitsuo, Shibata, Takayuki, Millington, Christopher L., Williams, David M., Takénaka, Akio
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965239/
https://www.ncbi.nlm.nih.gov/pubmed/20554855
http://dx.doi.org/10.1093/nar/gkq519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965239/
https://www.ncbi.nlm.nih.gov/pubmed/20554855
http://dx.doi.org/10.1093/nar/gkq519

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