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Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26

HDM2 is a p53-specific E3 ubiquitin ligase. Its overexpression leads to excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. HDM2 also affects the cell cycle, apoptosis and tumorigenesis through interacting with other molecules, including several ribosomal proteins...

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Detalles Bibliográficos
Autores principales:	Zhang, Ying, Wang, Jian, Yuan, Yanzhi, Zhang, Wanqiao, Guan, Wei, Wu, Zhihao, Jin, Chaozhi, Chen, Hui, Zhang, Lingqiang, Yang, Xiaoming, He, Fuchu
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965247/ https://www.ncbi.nlm.nih.gov/pubmed/20542919 http://dx.doi.org/10.1093/nar/gkq536

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