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The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage

Regulation of ribonucleotide reductase (RNR) is important for cell survival and genome integrity in the face of genotoxic stress. The Mec1/Rad53/Dun1 DNA damage response kinase cascade exhibits multifaceted controls over RNR activity including the regulation of the RNR inhibitor, Sml1. After DNA dam...

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Detalles Bibliográficos
Autores principales:	Andreson, Bethany L., Gupta, Amitabha, Georgieva, Bilyana P., Rothstein, Rodney
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965251/ https://www.ncbi.nlm.nih.gov/pubmed/20566477 http://dx.doi.org/10.1093/nar/gkq552

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