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Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1α Have an Antagonistic Connection
The tumor suppressor adenomatous polyposis coli (APC) is mutated in the majority of colorectal cancers and is best known for its role as a scaffold in a Wnt-regulated protein complex that determines the availability of β-catenin. Another common feature of solid tumors is the presence of hypoxia as i...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965681/ https://www.ncbi.nlm.nih.gov/pubmed/20844082 http://dx.doi.org/10.1091/mbc.E10-04-0312 |