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Cell Type–dependent Requirement for PIP Box–regulated Cdt1 Destruction During S Phase

DNA synthesis–coupled proteolysis of the prereplicative complex component Cdt1 by the CRL4(Cdt2) E3 ubiquitin ligase is thought to help prevent rereplication of the genome during S phase. To directly test whether CRL4(Cdt2)-triggered destruction of Cdt1 is required for normal cell cycle progression...

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Detalles Bibliográficos
Autores principales:	Lee, Hyun O., Zacharek, Sima J., Xiong, Yue, Duronio, Robert J.
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2010
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965682/ https://www.ncbi.nlm.nih.gov/pubmed/20826610 http://dx.doi.org/10.1091/mbc.E10-02-0130

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