Dual Functions of Yeast tRNA Ligase in the Unfolded Protein Response: Unconventional Cytoplasmic Splicing of HAC1 Pre-mRNA Is Not Sufficient to Release Translational Attenuation

The unfolded protein response (UPR) is an essential signal transduction to cope with protein-folding stress in the endoplasmic reticulum. In the yeast UPR, the unconventional splicing of HAC1 mRNA is a key step. Translation of HAC1 pre-mRNA (HAC1(u) mRNA) is attenuated on polysomes and restarted onl...

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Detalles Bibliográficos
Autores principales: Mori, Takao, Ogasawara, Chiharu, Inada, Toshifumi, Englert, Markus, Beier, Hildburg, Takezawa, Mine, Endo, Toshiya, Yoshihisa, Tohru
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965688/
https://www.ncbi.nlm.nih.gov/pubmed/20844078
http://dx.doi.org/10.1091/mbc.E10-08-0693

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