Conserved Genes Act as Modifiers of Invertebrate SMN Loss of Function Defects

Spinal Muscular Atrophy (SMA) is caused by diminished function of the Survival of Motor Neuron (SMN) protein, but the molecular pathways critical for SMA pathology remain elusive. We have used genetic approaches in invertebrate models to identify conserved SMN loss of function modifier genes. Drosop...

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Detalles Bibliográficos
Autores principales: Dimitriadi, Maria, Sleigh, James N., Walker, Amy, Chang, Howard C., Sen, Anindya, Kalloo, Geetika, Harris, Jevede, Barsby, Tom, Walsh, Melissa B., Satterlee, John S., Li, Chris, Van Vactor, David, Artavanis-Tsakonas, Spyros, Hart, Anne C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965752/
https://www.ncbi.nlm.nih.gov/pubmed/21124729
http://dx.doi.org/10.1371/journal.pgen.1001172

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