Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey

BACKGROUND: The etiology of esophageal squamous cell cancer (ESCC) in high prevalence regions of China remains unclear. METHODS: Endoscopic biopsies were conducted among 7381 inhabitants aged from 25 to 65 of Anyang, China. RESULTS: In this study, 2.57, 0.20 and 0.16% of the participants had mild, m...

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Autores principales: He, Z, Zhao, Y, Guo, C, Liu, Y, Sun, M, Liu, F, Wang, X, Guo, F, Chen, K, Gao, L, Ning, T, Pan, Y, Li, Y, Zhang, S, Lu, C, Wang, Z, Cai, H, Ke, Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
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Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965859/
https://www.ncbi.nlm.nih.gov/pubmed/20700119
http://dx.doi.org/10.1038/sj.bjc.6605843
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author He, Z
Zhao, Y
Guo, C
Liu, Y
Sun, M
Liu, F
Wang, X
Guo, F
Chen, K
Gao, L
Ning, T
Pan, Y
Li, Y
Zhang, S
Lu, C
Wang, Z
Cai, H
Ke, Y
author_facet He, Z
Zhao, Y
Guo, C
Liu, Y
Sun, M
Liu, F
Wang, X
Guo, F
Chen, K
Gao, L
Ning, T
Pan, Y
Li, Y
Zhang, S
Lu, C
Wang, Z
Cai, H
Ke, Y
author_sort He, Z
collection PubMed
description BACKGROUND: The etiology of esophageal squamous cell cancer (ESCC) in high prevalence regions of China remains unclear. METHODS: Endoscopic biopsies were conducted among 7381 inhabitants aged from 25 to 65 of Anyang, China. RESULTS: In this study, 2.57, 0.20 and 0.16% of the participants had mild, moderate and severe squamous dysplasia, respectively; 0.19 and 0.08% showed squamous carcinoma in situ and invasive ESCC. Using deep well (depth >100 meters) as water source (odds ratio=0.72, 95% confidence interval: 0.54–0.96) was negatively associated with ESCC and its precursors, whereas tobacco and alcohol use were not significantly associated with ESCC. CONCLUSIONS: Water source and other factors in this region need further evaluation by longitudinal studies.
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spelling pubmed-29658592011-09-28 Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey He, Z Zhao, Y Guo, C Liu, Y Sun, M Liu, F Wang, X Guo, F Chen, K Gao, L Ning, T Pan, Y Li, Y Zhang, S Lu, C Wang, Z Cai, H Ke, Y Br J Cancer Short Communication BACKGROUND: The etiology of esophageal squamous cell cancer (ESCC) in high prevalence regions of China remains unclear. METHODS: Endoscopic biopsies were conducted among 7381 inhabitants aged from 25 to 65 of Anyang, China. RESULTS: In this study, 2.57, 0.20 and 0.16% of the participants had mild, moderate and severe squamous dysplasia, respectively; 0.19 and 0.08% showed squamous carcinoma in situ and invasive ESCC. Using deep well (depth >100 meters) as water source (odds ratio=0.72, 95% confidence interval: 0.54–0.96) was negatively associated with ESCC and its precursors, whereas tobacco and alcohol use were not significantly associated with ESCC. CONCLUSIONS: Water source and other factors in this region need further evaluation by longitudinal studies. Nature Publishing Group 2010-09-28 2010-08-10 /pmc/articles/PMC2965859/ /pubmed/20700119 http://dx.doi.org/10.1038/sj.bjc.6605843 Text en Copyright © 2010 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
He, Z
Zhao, Y
Guo, C
Liu, Y
Sun, M
Liu, F
Wang, X
Guo, F
Chen, K
Gao, L
Ning, T
Pan, Y
Li, Y
Zhang, S
Lu, C
Wang, Z
Cai, H
Ke, Y
Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey
title Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey
title_full Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey
title_fullStr Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey
title_full_unstemmed Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey
title_short Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey
title_sort prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in anyang, china: a population-based endoscopic survey
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965859/
https://www.ncbi.nlm.nih.gov/pubmed/20700119
http://dx.doi.org/10.1038/sj.bjc.6605843
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