Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer

BACKGROUND: AMP-activated protein kinase (AMPK, PRKA) has central roles in cellular metabolic sensing and energy balance homeostasis, and interacts with various pathways (e.g., TP53 (p53), FASN, MTOR and MAPK3/1 (ERK)). AMP-activated protein kinase activation is cytotoxic to cancer cells, supporting...

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Detalles Bibliográficos
Autores principales: Baba, Y, Nosho, K, Shima, K, Meyerhardt, J A, Chan, A T, Engelman, J A, Cantley, L C, Loda, M, Giovannucci, E, Fuchs, C S, Ogino, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965861/
https://www.ncbi.nlm.nih.gov/pubmed/20808308
http://dx.doi.org/10.1038/sj.bjc.6605846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965861/
https://www.ncbi.nlm.nih.gov/pubmed/20808308
http://dx.doi.org/10.1038/sj.bjc.6605846

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