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Prognostic role of EGFR gene copy number and KRAS mutation in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy

BACKGROUND: Epidermal growth factor receptor (EGFR), evaluated by immunohistochemistry, has been shown to have prognostic significance in patients with colorectal cancer. Gene copy number (GCN) of EGFR and KRAS status predict response and outcome in patients treated with anti-EGFR therapy, but their...

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Detalles Bibliográficos
Autores principales:	Bengala, C, Bettelli, S, Bertolini, F, Sartori, G, Fontana, A, Malavasi, N, Depenni, R, Zironi, S, Del Giovane, C, Luppi, G, Conte, P F
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965865/ https://www.ncbi.nlm.nih.gov/pubmed/20842128 http://dx.doi.org/10.1038/sj.bjc.6605853

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