What lessons can be learned from studying the folding of homologous proteins?

The studies of the folding of structurally related proteins have proved to be a very important tool for investigating protein folding. Here we review some of the insights that have been gained from such studies. Our highlighted studies show just how such an investigation should be designed and empha...

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Detalles Bibliográficos
Autores principales: Nickson, Adrian A., Clarke, Jane
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965948/
https://www.ncbi.nlm.nih.gov/pubmed/20570731
http://dx.doi.org/10.1016/j.ymeth.2010.06.003
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author Nickson, Adrian A.
Clarke, Jane
author_facet Nickson, Adrian A.
Clarke, Jane
author_sort Nickson, Adrian A.
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description The studies of the folding of structurally related proteins have proved to be a very important tool for investigating protein folding. Here we review some of the insights that have been gained from such studies. Our highlighted studies show just how such an investigation should be designed and emphasise the importance of the synergy between experiment and theory. We also stress the importance of choosing the right system carefully, exploiting the excellent structural and sequence databases at our disposal.
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spelling pubmed-29659482010-11-08 What lessons can be learned from studying the folding of homologous proteins? Nickson, Adrian A. Clarke, Jane Methods Review Article The studies of the folding of structurally related proteins have proved to be a very important tool for investigating protein folding. Here we review some of the insights that have been gained from such studies. Our highlighted studies show just how such an investigation should be designed and emphasise the importance of the synergy between experiment and theory. We also stress the importance of choosing the right system carefully, exploiting the excellent structural and sequence databases at our disposal. Academic Press 2010-09 /pmc/articles/PMC2965948/ /pubmed/20570731 http://dx.doi.org/10.1016/j.ymeth.2010.06.003 Text en © 2010 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Review Article
Nickson, Adrian A.
Clarke, Jane
What lessons can be learned from studying the folding of homologous proteins?
title What lessons can be learned from studying the folding of homologous proteins?
title_full What lessons can be learned from studying the folding of homologous proteins?
title_fullStr What lessons can be learned from studying the folding of homologous proteins?
title_full_unstemmed What lessons can be learned from studying the folding of homologous proteins?
title_short What lessons can be learned from studying the folding of homologous proteins?
title_sort what lessons can be learned from studying the folding of homologous proteins?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965948/
https://www.ncbi.nlm.nih.gov/pubmed/20570731
http://dx.doi.org/10.1016/j.ymeth.2010.06.003
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