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New Hierarchical Phosphorylation Pathway of the Translational Repressor eIF4E-binding Protein 1 (4E-BP1) in Ischemia-Reperfusion Stress

Eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) is a translational repressor that is characterized by its capacity to bind specifically to eIF4E and inhibit its interaction with eIF4G. Phosphorylation of 4E-BP1 regulates eIF4E availability, and therefore, cap-dependent translation,...

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Detalles Bibliográficos
Autores principales:	Ayuso, María I., Hernández-Jiménez, Macarena, Martín, María E., Salinas, Matilde, Alcázar, Alberto
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Protein Synthesis and Degradation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966049/ https://www.ncbi.nlm.nih.gov/pubmed/20736160 http://dx.doi.org/10.1074/jbc.M110.135103

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