TPC2 Is a Novel NAADP-sensitive Ca(2+) Release Channel, Operating as a Dual Sensor of Luminal pH and Ca(2+)

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a molecule capable of initiating the release of intracellular Ca(2+) required for many essential cellular processes. Recent evidence links two-pore channels (TPCs) with NAADP-induced release of Ca(2+) from lysosome-like acidic organelles; howe...

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Detalles Bibliográficos
Autores principales: Pitt, Samantha J., Funnell, Tim M., Sitsapesan, Mano, Venturi, Elisa, Rietdorf, Katja, Ruas, Margarida, Ganesan, A., Gosain, Rajendra, Churchill, Grant C., Zhu, Michael X., Parrington, John, Galione, Antony, Sitsapesan, Rebecca
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966118/
https://www.ncbi.nlm.nih.gov/pubmed/20720007
http://dx.doi.org/10.1074/jbc.M110.156927

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