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The value of avian genomics to the conservation of wildlife

BACKGROUND: Genomic studies in non-domestic avian models, such as the California condor and white-throated sparrow, can lead to more comprehensive conservation plans and provide clues for understanding mechanisms affecting genetic variation, adaptation and evolution. Developing genomic tools and res...

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Autores principales: Romanov, Michael N, Tuttle, Elaina M, Houck, Marlys L, Modi, William S, Chemnick, Leona G, Korody, Marisa L, Mork, Emily M Stremel, Otten, Christie A, Renner, Tanya, Jones, Kenneth C, Dandekar, Sugandha, Papp, Jeanette C, Da, Yang, Green, Eric D, Magrini, Vincent, Hickenbotham, Matthew T, Glasscock, Jarret, McGrath, Sean, Mardis, Elaine R, Ryder, Oliver A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966331/
https://www.ncbi.nlm.nih.gov/pubmed/19607652
http://dx.doi.org/10.1186/1471-2164-10-S2-S10
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author Romanov, Michael N
Tuttle, Elaina M
Houck, Marlys L
Modi, William S
Chemnick, Leona G
Korody, Marisa L
Mork, Emily M Stremel
Otten, Christie A
Renner, Tanya
Jones, Kenneth C
Dandekar, Sugandha
Papp, Jeanette C
Da, Yang
Green, Eric D
Magrini, Vincent
Hickenbotham, Matthew T
Glasscock, Jarret
McGrath, Sean
Mardis, Elaine R
Ryder, Oliver A
author_facet Romanov, Michael N
Tuttle, Elaina M
Houck, Marlys L
Modi, William S
Chemnick, Leona G
Korody, Marisa L
Mork, Emily M Stremel
Otten, Christie A
Renner, Tanya
Jones, Kenneth C
Dandekar, Sugandha
Papp, Jeanette C
Da, Yang
Green, Eric D
Magrini, Vincent
Hickenbotham, Matthew T
Glasscock, Jarret
McGrath, Sean
Mardis, Elaine R
Ryder, Oliver A
author_sort Romanov, Michael N
collection PubMed
description BACKGROUND: Genomic studies in non-domestic avian models, such as the California condor and white-throated sparrow, can lead to more comprehensive conservation plans and provide clues for understanding mechanisms affecting genetic variation, adaptation and evolution. Developing genomic tools and resources including genomic libraries and a genetic map of the California condor is a prerequisite for identification of candidate loci for a heritable embryonic lethal condition. The white-throated sparrow exhibits a stable genetic polymorphism (i.e. chromosomal rearrangements) associated with variation in morphology, physiology, and behavior (e.g., aggression, social behavior, sexual behavior, parental care). In this paper we outline the utility of these species as well as report on recent advances in the study of their genomes. RESULTS: Genotyping of the condor resource population at 17 microsatellite loci provided a better assessment of the current population's genetic variation. Specific New World vulture repeats were found in the condor genome. Using condor BAC library and clones, chicken-condor comparative maps were generated. A condor fibroblast cell line transcriptome was characterized using the 454 sequencing technology. Our karyotypic analyses of the sparrow in combination with other studies indicate that the rearrangements in both chromosomes 2(m )and 3(a )are complex and likely involve multiple inversions, interchromosomal linkage, and pleiotropy. At least a portion of the rearrangement in chromosome 2(m )existed in the common ancestor of the four North American species of Zonotrichia, but not in the one South American species, and that the 2(m )form, originally thought to be the derived condition, might actually be the ancestral one. CONCLUSION: Mining and characterization of candidate loci in the California condor using molecular genetic and genomic techniques as well as linkage and comparative genomic mapping will eventually enable the identification of carriers of the chondrodystrophy allele, resulting in improved genetic management of this disease. In the white-throated sparrow, genomic studies, combined with ecological data, will help elucidate the basis of genic selection in a natural population. Morphs of the sparrow provide us with a unique opportunity to study intraspecific genomic differences, which have resulted from two separate yet linked evolutionary trajectories. Such results can transform our understanding of evolutionary and conservation biology.
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spelling pubmed-29663312010-10-29 The value of avian genomics to the conservation of wildlife Romanov, Michael N Tuttle, Elaina M Houck, Marlys L Modi, William S Chemnick, Leona G Korody, Marisa L Mork, Emily M Stremel Otten, Christie A Renner, Tanya Jones, Kenneth C Dandekar, Sugandha Papp, Jeanette C Da, Yang Green, Eric D Magrini, Vincent Hickenbotham, Matthew T Glasscock, Jarret McGrath, Sean Mardis, Elaine R Ryder, Oliver A BMC Genomics Proceedings BACKGROUND: Genomic studies in non-domestic avian models, such as the California condor and white-throated sparrow, can lead to more comprehensive conservation plans and provide clues for understanding mechanisms affecting genetic variation, adaptation and evolution. Developing genomic tools and resources including genomic libraries and a genetic map of the California condor is a prerequisite for identification of candidate loci for a heritable embryonic lethal condition. The white-throated sparrow exhibits a stable genetic polymorphism (i.e. chromosomal rearrangements) associated with variation in morphology, physiology, and behavior (e.g., aggression, social behavior, sexual behavior, parental care). In this paper we outline the utility of these species as well as report on recent advances in the study of their genomes. RESULTS: Genotyping of the condor resource population at 17 microsatellite loci provided a better assessment of the current population's genetic variation. Specific New World vulture repeats were found in the condor genome. Using condor BAC library and clones, chicken-condor comparative maps were generated. A condor fibroblast cell line transcriptome was characterized using the 454 sequencing technology. Our karyotypic analyses of the sparrow in combination with other studies indicate that the rearrangements in both chromosomes 2(m )and 3(a )are complex and likely involve multiple inversions, interchromosomal linkage, and pleiotropy. At least a portion of the rearrangement in chromosome 2(m )existed in the common ancestor of the four North American species of Zonotrichia, but not in the one South American species, and that the 2(m )form, originally thought to be the derived condition, might actually be the ancestral one. CONCLUSION: Mining and characterization of candidate loci in the California condor using molecular genetic and genomic techniques as well as linkage and comparative genomic mapping will eventually enable the identification of carriers of the chondrodystrophy allele, resulting in improved genetic management of this disease. In the white-throated sparrow, genomic studies, combined with ecological data, will help elucidate the basis of genic selection in a natural population. Morphs of the sparrow provide us with a unique opportunity to study intraspecific genomic differences, which have resulted from two separate yet linked evolutionary trajectories. Such results can transform our understanding of evolutionary and conservation biology. BioMed Central 2009-07-14 /pmc/articles/PMC2966331/ /pubmed/19607652 http://dx.doi.org/10.1186/1471-2164-10-S2-S10 Text en Copyright ©2009 Romanov et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Romanov, Michael N
Tuttle, Elaina M
Houck, Marlys L
Modi, William S
Chemnick, Leona G
Korody, Marisa L
Mork, Emily M Stremel
Otten, Christie A
Renner, Tanya
Jones, Kenneth C
Dandekar, Sugandha
Papp, Jeanette C
Da, Yang
Green, Eric D
Magrini, Vincent
Hickenbotham, Matthew T
Glasscock, Jarret
McGrath, Sean
Mardis, Elaine R
Ryder, Oliver A
The value of avian genomics to the conservation of wildlife
title The value of avian genomics to the conservation of wildlife
title_full The value of avian genomics to the conservation of wildlife
title_fullStr The value of avian genomics to the conservation of wildlife
title_full_unstemmed The value of avian genomics to the conservation of wildlife
title_short The value of avian genomics to the conservation of wildlife
title_sort value of avian genomics to the conservation of wildlife
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966331/
https://www.ncbi.nlm.nih.gov/pubmed/19607652
http://dx.doi.org/10.1186/1471-2164-10-S2-S10
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