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Upregulation of Barrel GABAergic Neurons Is Associated with Cross-Modal Plasticity in Olfactory Deficit

BACKGROUND: Loss of a sensory function is often followed by the hypersensitivity of other modalities in mammals, which secures them well-awareness to environmental changes. Cellular and molecular mechanisms underlying cross-modal sensory plasticity remain to be documented. METHODOLOGY/PRINCIPAL FIND...

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Autores principales: Ni, Hong, Huang, Li, Chen, Na, Zhang, Fengyu, Liu, Dongbo, Ge, Ming, Guan, Sudong, Zhu, Yan, Wang, Jin-Hui
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966404/
https://www.ncbi.nlm.nih.gov/pubmed/21060832
http://dx.doi.org/10.1371/journal.pone.0013736
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author Ni, Hong
Huang, Li
Chen, Na
Zhang, Fengyu
Liu, Dongbo
Ge, Ming
Guan, Sudong
Zhu, Yan
Wang, Jin-Hui
author_facet Ni, Hong
Huang, Li
Chen, Na
Zhang, Fengyu
Liu, Dongbo
Ge, Ming
Guan, Sudong
Zhu, Yan
Wang, Jin-Hui
author_sort Ni, Hong
collection PubMed
description BACKGROUND: Loss of a sensory function is often followed by the hypersensitivity of other modalities in mammals, which secures them well-awareness to environmental changes. Cellular and molecular mechanisms underlying cross-modal sensory plasticity remain to be documented. METHODOLOGY/PRINCIPAL FINDINGS: Multidisciplinary approaches, such as electrophysiology, behavioral task and immunohistochemistry, were used to examine the involvement of specific types of neurons in cross-modal plasticity. We have established a mouse model that olfactory deficit leads to a whisking upregulation, and studied how GABAergic neurons are involved in this cross-modal plasticity. In the meantime of inducing whisker tactile hypersensitivity, the olfactory injury recruits more GABAergic neurons and their fine processes in the barrel cortex, as well as upregulates their capacity of encoding action potentials. The hyperpolarization driven by inhibitory inputs strengthens the encoding ability of their target cells. CONCLUSION/SIGNIFICANCE: The upregulation of GABAergic neurons and the functional enhancement of neuronal networks may play an important role in cross-modal sensory plasticity. This finding provides the clues for developing therapeutic approaches to help sensory recovery and substitution.
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spelling pubmed-29664042010-11-08 Upregulation of Barrel GABAergic Neurons Is Associated with Cross-Modal Plasticity in Olfactory Deficit Ni, Hong Huang, Li Chen, Na Zhang, Fengyu Liu, Dongbo Ge, Ming Guan, Sudong Zhu, Yan Wang, Jin-Hui PLoS One Research Article BACKGROUND: Loss of a sensory function is often followed by the hypersensitivity of other modalities in mammals, which secures them well-awareness to environmental changes. Cellular and molecular mechanisms underlying cross-modal sensory plasticity remain to be documented. METHODOLOGY/PRINCIPAL FINDINGS: Multidisciplinary approaches, such as electrophysiology, behavioral task and immunohistochemistry, were used to examine the involvement of specific types of neurons in cross-modal plasticity. We have established a mouse model that olfactory deficit leads to a whisking upregulation, and studied how GABAergic neurons are involved in this cross-modal plasticity. In the meantime of inducing whisker tactile hypersensitivity, the olfactory injury recruits more GABAergic neurons and their fine processes in the barrel cortex, as well as upregulates their capacity of encoding action potentials. The hyperpolarization driven by inhibitory inputs strengthens the encoding ability of their target cells. CONCLUSION/SIGNIFICANCE: The upregulation of GABAergic neurons and the functional enhancement of neuronal networks may play an important role in cross-modal sensory plasticity. This finding provides the clues for developing therapeutic approaches to help sensory recovery and substitution. Public Library of Science 2010-10-29 /pmc/articles/PMC2966404/ /pubmed/21060832 http://dx.doi.org/10.1371/journal.pone.0013736 Text en Ni et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ni, Hong
Huang, Li
Chen, Na
Zhang, Fengyu
Liu, Dongbo
Ge, Ming
Guan, Sudong
Zhu, Yan
Wang, Jin-Hui
Upregulation of Barrel GABAergic Neurons Is Associated with Cross-Modal Plasticity in Olfactory Deficit
title Upregulation of Barrel GABAergic Neurons Is Associated with Cross-Modal Plasticity in Olfactory Deficit
title_full Upregulation of Barrel GABAergic Neurons Is Associated with Cross-Modal Plasticity in Olfactory Deficit
title_fullStr Upregulation of Barrel GABAergic Neurons Is Associated with Cross-Modal Plasticity in Olfactory Deficit
title_full_unstemmed Upregulation of Barrel GABAergic Neurons Is Associated with Cross-Modal Plasticity in Olfactory Deficit
title_short Upregulation of Barrel GABAergic Neurons Is Associated with Cross-Modal Plasticity in Olfactory Deficit
title_sort upregulation of barrel gabaergic neurons is associated with cross-modal plasticity in olfactory deficit
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966404/
https://www.ncbi.nlm.nih.gov/pubmed/21060832
http://dx.doi.org/10.1371/journal.pone.0013736
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