ARHGEF7 (BETA-PIX) Acts as Guanine Nucleotide Exchange Factor for Leucine-Rich Repeat Kinase 2

BACKGROUND: Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that the rho guanine...

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Detalles Bibliográficos
Autores principales: Haebig, Karina, Gloeckner, Christian Johannes, Miralles, Marta Garcia, Gillardon, Frank, Schulte, Claudia, Riess, Olaf, Ueffing, Marius, Biskup, Saskia, Bonin, Michael
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966438/
https://www.ncbi.nlm.nih.gov/pubmed/21048939
http://dx.doi.org/10.1371/journal.pone.0013762

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